SH3KBP1: A Potential Drug Target and Biomarker (G30011)

Target Name: SH3KBP1

NCBI ID: G30011

SH3KBP1

SH3KBP1: A Potential Drug Target and Biomarker

SH3KBP1, also known as hsp70B2, is a heat shock protein (HSP) that is expressed in various tissues and cells, including the brain, heart, liver, and muscle. It is a member of the HSP70 family, which is known for their ability to withstand and recover from thermal stress, including exercise-induced stress.

Recent studies have identified SH3KBP1 as a potential drug target in the treatment of various diseases, including heart failure, liver disease, and neurodegenerative disorders. Its expression has also been linked to various cellular processes, including cell stress, apoptosis, and inflammation.

One of the reasons for the potential drug targeting of SH3KBP1 is its role in the regulation of cellular stress responses. SH3KBP1 has been shown to play a key role in the detoxification of cellular stress, which is caused by various factors, including exercise, UV radiation, and chemotherapy.

In addition, SH3KBP1 has been shown to regulate the expression of genes involved in cell stress and apoptosis. This regulation is critical for maintaining cellular homeostasis and has implications for the treatment of diseases that are characterized by cellular dysfunction and stress.

Another potential drug target for SH3KBP1 is its role in the regulation of inflammation. SH3KBP1 has been shown to play a key role in the regulation of inflammation and has been linked to various inflammatory diseases, including heart failure and neurodegenerative disorders.

In conclusion, SH3KBP1 is a promising drug target and biomarker for the treatment of various diseases. Further research is needed to fully understand its role in the regulation of cellular stress and inflammation and to develop effective therapies based on its properties.

Protein Name: SH3 Domain Containing Kinase Binding Protein 1

Functions: Adapter protein involved in regulating diverse signal transduction pathways. Involved in the regulation of endocytosis and lysosomal degradation of ligand-induced receptor tyrosine kinases, including EGFR and MET/hepatocyte growth factor receptor, through an association with CBL and endophilins. The association with CBL, and thus the receptor internalization, may be inhibited by an interaction with PDCD6IP and/or SPRY2. Involved in regulation of ligand-dependent endocytosis of the IgE receptor. Attenuates phosphatidylinositol 3-kinase activity by interaction with its regulatory subunit (By similarity). May be involved in regulation of cell adhesion; promotes the interaction between TTK2B and PDCD6IP. May be involved in the regulation of cellular stress response via the MAPK pathways through its interaction with MAP3K4. Is involved in modulation of tumor necrosis factor mediated apoptosis. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. Has an essential role in the stimulation of B cell activation (PubMed:29636373)

The "SH3KBP1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about SH3KBP1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets