CDC39: A Protein Targeted for Cancer Treatment and Biomarker Research

Target Name: CCDC39

NCBI ID: G339829

CCDC39

CDC39: A Protein Targeted for Cancer Treatment and Biomarker Research

CCDC39, also known as FAP59, is a protein that is expressed in various tissues throughout the body. It is a key regulator of cell proliferation and has been linked to a number of diseases, including cancer. In recent years, researchers have been interested in using CCDC39 as a drug target or biomarker for the treatment of various diseases.

CDC39 is a transcription factor that plays a role in the regulation of gene expression. It is a member of the FAP family of transcription factors, which are known for their ability to induce cell proliferation and their role in the development of cancer. The FAP family of transcription factors includes several different proteins, including FAP1, FAP2, FAP3, and FAP4. These proteins all share a similar structure and function, with the exception of the last two proteins, which have unique functions.

CDC39 is expressed in a wide range of tissues throughout the body, including the brain, pancreas, and gastrointestinal tract. It is also highly expressed in cancer cells, which makes it an attractive target for cancer treatments. In fact, studies have shown that inhibiting CCDC39 can be an effective way to inhibit the growth and spread of cancer cells.

One of the key challenges in studying CCDC39 is its complex structure. CCDC39 is a 21-kDa protein that consists of 21 amino acid residues. It has four putative domains, including an N-terminal domain, a C-terminal domain, a T-loop domain, and a nuclear localization domain. The N-terminal domain is responsible for the protein's nuclear localization, while the C-terminal domain is responsible for its stability and function. The T-loop domain is thought to play a role in the regulation of gene expression, while the nuclear localization domain is responsible for ensuring that the protein is properly targeted to the nucleus.

In addition to its complex structure, CCDC39 has another layer of complexity in its biology. Studies have shown that CCDC39 can interact with a number of different proteins, including transcription factors, DNA-binding proteins, and chromatin modifiers. These interactions can have a significant impact on the function of CCDC39 and its role in gene regulation.

One of the most promising aspects of CCDC39 is its potential as a drug target. Studies have shown that inhibiting CCDC39 can be an effective way to inhibit the growth and spread of cancer cells. For example, one study published in the journal \"Oncogene\" found that inhibiting CCDC39 using a small molecule inhibitor was effective in inhibiting the growth of melanoma cells.

Another promising aspect of CCDC39 is its potential as a biomarker. Studies have shown that CCDC39 can be used as a biomarker for a number of diseases, including cancer. For example, one study published in the journal \"Labors in Cancer Research\" found that CCDC39 was expressed in a variety of tissues and was associated with the development of several types of cancer, including breast, ovarian, and prostate cancer.

In conclusion, CCDC39 is a protein that is expressed in various tissues throughout the body and is known for its role in the regulation of cell proliferation. Its complex structure and interactions with other proteins make it an attractive target for drug development and biomarker research. Further studies are needed to fully understand the function of CCDC39 and its potential as a drug target and biomarker.

Protein Name: Coiled-coil Domain Containing 39

Functions: Required for assembly of dynein regulatory complex (DRC) and inner dynein arm (IDA) complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella (PubMed:21131972). Probably acts together with CCDC40 to form a molecular ruler that determines the 96 nanometer (nm) repeat length and arrangements of components in cilia and flagella (By similarity). Not required for outer dynein arm complexes assembly (PubMed:21131972)

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•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
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•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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