SLIT2: A Protein Implicated in Neurodegenerative Diseases (G9353)

Target Name: SLIT2

NCBI ID: G9353

SLIT2

SLIT2: A Protein Implicated in Neurodegenerative Diseases

SLIT2 (slit2) is a protein that is expressed in the brain and is known for its role in the development and progression of various neurological disorders, including Alzheimer's disease. The SLIT2 gene has four splice variants, each of which produces a different isoform of the protein.

The SLIT2 protein is a member of the SLIT family of proteins, which are known for their role in the regulation of cell death and survival. The SLIT2 gene has been implicated in the development and progression of neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and Huntington's disease.

The SLIT2 protein is synthesized in the brain and is highly expressed in regions of the brain that are affected by these disorders. It is thought to play a role in the regulation of neurotransmitter release and in the maintenance of cellular homeostasis.

Studies have suggested that SLIT2 may be a drug target or biomarker for the treatment of neurodegenerative diseases. By inhibiting the activity of SLIT2, it may be possible to reduce the severity and progression of these diseases.

One way to target SLIT2 is through the use of small molecules, such as those that can inhibit the activity of the protein. This approach has been used to develop potential drugs for the treatment of various neurological disorders, including Alzheimer's disease.

Another approach to targeting SLIT2 is through the use of antibodies that are designed to selectively bind to the protein. This approach has been used to develop potential drugs for the treatment of neurodegenerative diseases, including Alzheimer's disease.

In addition to its potential as a drug target, SLIT2 has also been suggested as a potential biomarker for the diagnosis and monitoring of neurodegenerative diseases. The levels of SLIT2 protein have been shown to be reduced in the brains of individuals with Alzheimer's disease, and this reduction may be an indicator of the severity and progression of the disease.

Overall, SLIT2 is a protein that is of interest as a drug target or biomarker for the treatment of neurodegenerative diseases. Further research is needed to fully understand its role in these conditions and to develop effective treatments.

Protein Name: Slit Guidance Ligand 2

Functions: Thought to act as molecular guidance cue in cellular migration, and function appears to be mediated by interaction with roundabout homolog receptors. During neural development involved in axonal navigation at the ventral midline of the neural tube and projection of axons to different regions. SLIT1 and SLIT2 seem to be essential for midline guidance in the forebrain by acting as repulsive signal preventing inappropriate midline crossing by axons projecting from the olfactory bulb. In spinal cord development may play a role in guiding commissural axons once they reached the floor plate by modulating the response to netrin. In vitro, silences the attractive effect of NTN1 but not its growth-stimulatory effect and silencing requires the formation of a ROBO1-DCC complex. May be implicated in spinal cord midline post-crossing axon repulsion. In vitro, only commissural axons that crossed the midline responded to SLIT2. In the developing visual system appears to function as repellent for retinal ganglion axons by providing a repulsion that directs these axons along their appropriate paths prior to, and after passage through, the optic chiasm. In vitro, collapses and repels retinal ganglion cell growth cones. Seems to play a role in branching and arborization of CNS sensory axons, and in neuronal cell migration. In vitro, Slit homolog 2 protein N-product, but not Slit homolog 2 protein C-product, repels olfactory bulb (OB) but not dorsal root ganglia (DRG) axons, induces OB growth cones collapse and induces branching of DRG axons. Seems to be involved in regulating leukocyte migration

The "SLIT2 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about SLIT2 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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