Discovering The Potential of INCENP as A Drug Target and Biomarker

Target Name: INCENP

NCBI ID: G3619

INCENP

Discovering The Potential of INCENP as A Drug Target and Biomarker

TheINCENP gene, located on chromosome 15, encodes for the protein known as Inner centromere protein (INCENP), which plays a crucial role in the proper formation of microtubules in the mitotic spindle.INCENP is a 21-kDa protein that is expressed in a variety of tissues, including muscle, brain, and heart. It is involved in the regulation of mitosis, meiosis, and cell division, and is considered a key regulator of the mitotic spindle.

Recent studies have identifiedINCENP as a potential drug target and biomarker for a variety of diseases, including cancer, neurodegenerative diseases, and developmental disorders. In this article, we will explore the biology and function of INCENP, as well as its potential as a drug target and biomarker.

Biochemistry and Proteomics

INCENP is a type of protein known as a microtubule-associated protein (MAP), which means it is associated with the mitotic spindle and is involved in the regulation of cell division. It is composed of a unique nucleotide-rich region, a transmembrane region, and an intracellular region. The transmembrane region of INCENP contains a variable region that is responsible for the protein's unique structure and function.

TheINCENP gene has four exons, which are located on the long arm of chromosome 15. The first exon codes for the amino acid residues that are present in the transmembrane region of the protein. The second exon codes for the amino acid residues that are present in the variable region. The third exon codes for the amino acid residues that are present in the intracellular region, and the fourth exon codes for the amino acid residues that are present in the C-terminus region.

Expression and Localization

INCENP is expressed in a variety of tissues and cells, including muscle, brain, and heart. It is highly expressed in muscle fibers, which are the functional units of muscle and are responsible for generating force. It is also expressed in the brain, where it is involved in the regulation of neuronal division and the development of neural circuits.

INCENP is primarily localized to the mitotic spindle, which is the structure that pulls the chromosomes apart during cell division. It is also involved in the regulation of the forces that are exerted on the spindle during mitosis and meiosis.

Drug Interference and Therapeutic Potential

INCENP has been identified as a potential drug target and biomarker due to its involvement in the regulation of cell division and the development of neural circuits. Many studies have shown that INCENP is involved in the regulation of neuronal division and that it plays a role in the development of neurodegenerative diseases.

One of the main challenges in targeting INCENP as a drug target is its high stability and the fact that it is expressed in a variety of tissues. However, recent studies have shown that INCENP can be effectively targeted by small molecules that are designed to disrupt its activity.

One of the most promising approaches to targeting INCENP is the use of small molecules that can inhibit its activity. These small molecules can be administered to animals or human beings, and their effects on INCENP expression and activity can be measured.

Another approach to targeting INCENP is the use of antibodies that are designed to specifically recognize and bind to the protein. These antibodies can be used to block the activity of INCENP, and its effects on

Protein Name: Inner Centromere Protein

Functions: Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Acts as a scaffold regulating CPC localization and activity. The C-terminus associates with AURKB or AURKC, the N-terminus associated with BIRC5/survivin and CDCA8/borealin tethers the CPC to the inner centromere, and the microtubule binding activity within the central SAH domain directs AURKB/C toward substrates near microtubules (PubMed:15316025, PubMed:12925766, PubMed:27332895). The flexibility of the SAH domain is proposed to allow AURKB/C to follow substrates on dynamic microtubules while ensuring CPC docking to static chromatin (By similarity). Activates AURKB and AURKC (PubMed:27332895). Required for localization of CBX5 to mitotic centromeres (PubMed:21346195). Controls the kinetochore localization of BUB1 (PubMed:16760428)

The "INCENP Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about INCENP comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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