CCDC178: A Protein Involved in Pain and Inflammation (G374864)

Target Name: CCDC178

NCBI ID: G374864

CCDC178

CCDC178: A Protein Involved in Pain and Inflammation

CCDC178 (MGC111498) is a protein that is expressed in various tissues of the body, including the brain, heart, and lungs. It is a member of the MGC family of G-protein-coupled receptors, which are a family of transmembrane proteins that play an important role in cellular signaling.

CCDC178 is known for its role in cell signaling, particularly in the regulation of pain perception and neuroinflammation. It is thought to function as a negative regulator of pain signaling, which means that when pain is detected, CCDC178 is activated and works to prevent the transmission of pain signals to the brain.

One of the ways that CCDC178 is involved in pain signaling is through its role in the production of pro-inflammatory cytokines. These cytokines, such as TNF-alpha, IL-1尾, and IL-6, are important for the recruitment of immune cells to the site of pain and for the production of further pro-inflammatory cytokines. By participating in the production of these cytokines, CCDC178 may contribute to the persistent inflammation that can follow pain injury.

Another way that CCDC178 is involved in pain signaling is through its role in the regulation of pain modalities. CCDC178 has been shown to regulate the production of nociceptive pain mediators, such as histamine and calcitonin, which are released by the endothelial cells that line the blood vessels that supply the injured tissue. This may contribute to the chronic pain that can follow injury, as the production of these pain mediators can provide a persistent source of pain signals.

In addition to its role in pain signaling, CCDC178 is also thought to be involved in the regulation of inflammation. It has been shown to play a negative role in the production of pro-inflammatory cytokines, which may help to prevent the recruitment of immune cells to the site of inflammation. This may contribute to the regulation of chronic inflammation, which can lead to a range of diseases, including chronic pain, neuroinflammatory diseases, and autoimmune disorders.

CCDC178 is also of interest as a potential drug target. For example, inhibitors of CCDC178 have been shown to be effective in reducing pain in animal models of pain, and have been tested in clinical trials for the treatment of neuroinflammatory diseases. Additionally, CCDC178 has been shown to be involved in the regulation of pain modalities, which may make it an attractive target for compounds that aim to modulate pain perception.

In conclusion, CCDC178 is a protein that is involved in a variety of cellular signaling processes in the body. Its role in cell signaling, particularly in the regulation of pain perception and neuroinflammation, makes it an attractive target for the development of new drugs for the treatment of pain and neuroinflammatory diseases. Further research is needed to fully understand the mechanisms of CCDC178 and its potential as a drug target.

Protein Name: Coiled-coil Domain Containing 178

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