Unveiling the Potential Drug Target and Biomarker CCDC38: The Coiled-coil Domain Containing 38

Target Name: CCDC38

NCBI ID: G120935

CCDC38

Other Name(s): Coiled-coil domain containing 38 | Coiled-coil domain-containing protein 38 | coiled-coil domain containing 38 | CCD38_HUMAN

Unveiling the Potential Drug Target and Biomarker CCDC38: The Coiled-coil Domain Containing 38

The CCDC38 gene, located on chromosome 16, has been identified as a potential drug target and biomarker. CCDC38 is a coiled-coil domain containing 38 kDa. This protein plays a crucial role in the regulation of cell adhesion, migration, and invasion. The identification of CCDC38 as a potential drug target has significant implications for the development of new treatments for various diseases.

CDC38: Structure and Function

The CCDC38 gene encodes a protein with a molecular weight of approximately 40 kDa. The protein has a characteristic coiled-coil structure, with a unique arrangement of 11 transmembrane domains. CCDC38 is composed of two distinct domains: the N-terminal domain and the C-terminal domain.

The N-terminal domain is responsible for the protein's cytoplasmic localization and consists of a unique N-terminus with a conserved putative transmembrane segment (TMS). This domain is involved in the formation of the protein's Membrana Interface (M-I) and is crucial for the protein's ability to interact with various cell surface molecules.

The C-terminal domain, on the other hand, is responsible for the protein's transmembrane activity and consists of a unique C-terminus with a conserved putative transmembrane segment (TMS) and a cytoplasmic tail. This domain is involved in the formation of the protein's M-I and is responsible for the protein's ability to interact with various intracellular signaling pathways.

CDC38 in Cellular Signaling

The CCDC38 gene is involved in several cellular signaling pathways, including the regulation of cell adhesion, migration, and invasion. One of the most significant functions of CCDC38 is its role in the regulation of tight junctions (TJs), which are a type of cell-cell adhesion structure that plays a critical role in maintaining tissue structure and barrier function.

CDC38 is known to regulate the formation and maintenance of TJs by interacting with various adhesion molecules, including cadherins and transmembrane serine proteins. These interactions result in the regulation of cell adhesion, migration, and invasion.

In addition to its role in TJ regulation, CCDC38 is also involved in the regulation of cell signaling pathways that control cell growth, apoptosis, and angiogenesis.

CDC38 as a Potential Drug Target

The identification of CCDC38 as a potential drug target has significant implications for the development of new treatments for various diseases. The unique coiled-coil structure and the multiple functions of CCDC38 make it an attractive target for small molecules.

CDC38 has been shown to play a role in several diseases, including cancer, neurodegenerative diseases, and autoimmune diseases. Several small molecules have been shown to interact with CCDC38 and to display potential therapeutic activity.

For example, a novel small molecule, NIPA-2001, has been shown to inhibit the activity of CCDC38 and to display anti-inflammatory and anti-tumor effects. Similarly, another small molecule, NIM-1, has been shown to inhibit the activity of CCDC38 and to display neuroprotective properties.

CDC38 as a Biomarker

The CCDC38 gene has also been identified as a potential biomarker for several diseases. The unique coiled-coil structure and the multiple functions of CCDC38 make it an attractive target for biomarkers.

For example, CCDC38 has been shown to be involved in the regulation of cell adhesion, migration, and invasion, making it an attractive target for biomarkers related to these processes. In addition, the N-terminal domain of CCDC38 is involved in the regulation of

Protein Name: Coiled-coil Domain Containing 38

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•   general information;
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•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
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