Target Name: MC1R
NCBI ID: G4157
Review Report on MC1R Target / Biomarker Content of Review Report on MC1R Target / Biomarker
MC1R
Other Name(s): Melanocyte-stimulating hormone receptor | SHEP2 | Melanocortin 1 receptor | melanocortin 1 receptor | melanotropin receptor | MC1-R | Melanotropin receptor | Melanocyte stimulating hormone receptor | MGC14337 | MSHR_HUMAN | MSH-R | CMM5 | Melanocortin receptor 1 | alpha melanocyte stimulating hormone receptor

MC1R: A GPCR Molecule Wrapped in Skin and Eye Pigmentation, Hair and Autoimmune Diseases

MC1R (Melanocyte-stimulating hormone receptor) is a protein that is expressed in melanocytes, which are the pigment-producing cells in the skin. It is a G protein-coupled receptor (GPCR), which means it is a transmembrane protein that is involved in intracellular signaling.

The MC1R gene was first identified in 2001 and has since been shown to be involved in a variety of biological processes, including skin pigmentation, hair growth, and eye color. It is also involved in the regulation of inflammation and has been shown to play a role in the development of skin diseases such as melanoma.

One of the unique aspects of MC1R is its role in skin pigmentation. MC1R is responsible for the production of melanin, which is the pigment that gives the skin its color. Melanin is produced by melanocytes and is essential for the maintenance of skin pigmentation.

In addition to its role in skin pigmentation, MC1R is also involved in the regulation of hair growth and the development of hair. It has been shown to play a role in the development of hair follicles and the growth of hair.

MC1R is also involved in the regulation of eye color. It is responsible for the production of the pigment melanin, which is responsible for the color of the iris. The amount of melanin produced by MC1R is regulated by the amount of light that enters the eye.

MC1R is also involved in the regulation of inflammation. It has been shown to play a role in the development of inflammatory diseases such as autoimmune disorders.

One of the potential applications of MC1R as a drug target is its potential to treat skin diseases such as melanoma. Because MC1R is involved in the regulation of skin pigmentation and hair growth, it is possible that targeting it with drugs could lead to the development of treatments for skin diseases.

Another potential application of MC1R is its potential as a biomarker for the diagnosis and monitoring of skin diseases. Because MC1R is involved in the regulation of skin pigmentation and hair growth, it is possible that analyzing the levels of MC1R in the skin could be a useful diagnostic tool for skin diseases.

MC1R is also involved in the regulation of eye color and has been shown to play a role in the development of inflammatory diseases. These properties make it a potential candidate for the development of drugs or biomarkers for a variety of diseases.

Protein Name: Melanocortin 1 Receptor

Functions: Receptor for MSH (alpha, beta and gamma) and ACTH (PubMed:1325670, PubMed:8463333, PubMed:1516719, PubMed:11442765, PubMed:11707265). The activity of this receptor is mediated by G proteins which activate adenylate cyclase (PubMed:1325670, PubMed:11707265, PubMed:16463023, PubMed:19737927). Mediates melanogenesis, the production of eumelanin (black/brown) and phaeomelanin (red/yellow), via regulation of cAMP signaling in melanocytes (PubMed:31097585)

The "MC1R Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about MC1R comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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