Exploring the Potential Drug Target ATOSB: Unlocking the Potential of Protein FAM214B

Target Name: ATOSB

NCBI ID: G80256

ATOSB

Exploring the Potential Drug Target ATOSB: Unlocking the Potential of Protein FAM214B

Introduction

ATOSB (Protein FAM214B) is a protein that has gained significant attention in recent years due to its unique structure and various functions. Firstly, it was discovered as a potential drug target in the FAM214B gene, which is associated with a range of diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. Secondly, the protein has been shown to play a crucial role in the regulation of cellular processes, including cell adhesion, migration, and invasion.

Molecular Structure and Functions

ATOSB is a 21-kDa protein that belongs to the FAM214B family, which is characterized by the presence of a unique N-terminal region containing a putative transmembrane domain and a N-terminal cytoplasmic domain. The cytoplasmic domain is rich in various conserved motifs, including a leucine-rich repeat (LRR), a glycine-rich repeat (GRR), and a putative glycophosphorylase (GPL) domain.

ATOSB has been shown to localize to the endoplasmic reticulum (ER) and to play a role in regulating the ER-GPL complex, which is responsible for the retrieval and transport of proteins from the ER to the cytosol. The ER-GPL complex is a well-established process that is vital for maintaining cellular homeostasis and has been implicated in various cellular processes, including cell growth, apoptosis, and autophagy.

In addition to its role in the ER-GPL complex, ATOSB has been shown to participate in the regulation of cellular adhesion and migration. ATOSB has been shown to interact with various cell surface molecules, including cadherins, integrins, and vimentin, and has been involved in the regulation of cell-cell adhesion and the movement of cells along the major tubes and microtubules.

ATOSB has also been shown to play a role in the regulation of cell proliferation and apoptosis. In various cellular models, ATOSB has been shown to promote the growth and survival of cancer cells, and to contribute to the development and progression of various types of cancer . This may be due to the various functions that ATOSB plays in cell signaling pathways, including the regulation of cell cycle progression and the inhibition of apoptosis.

Drug Target Potential

The potential drug target status of ATOSB is supported by its association with various diseases, including cancer. ATOSB has been shown to promote the growth and survival of various cancer cell types, including breast, ovarian, and colorectal cancer. This may be due to the Various functions that ATOSB plays in cell signaling pathways, including the regulation of cell cycle progression and the inhibition of apoptosis.

In addition to its association with cancer, ATOSB has also been shown to be involved in the regulation of neurodegenerative diseases. ATOSB has been shown to interact with various neurotransmitter receptors, including dopamine, serotonin, and GABA, and has been involved in the regulation of neurotransmitter signaling pathways. This may be due to the various functions that ATOSB plays in the regulation of cellular processes, including the regulation of neurotransmitter signaling pathways.

In conclusion, the protein ATOSB has a unique structure and functions that have implications for its potential as a drug target. The various roles that ATOSB plays in cellular processes, including its regulation of cell adhesion, migration, and apoptosis, as well as its association with cancer and neurodegenerative diseases, make it an attractive

Protein Name: Atos Homolog B

Functions: Transcription regulator that may syncronize transcriptional and translational programs

The "ATOSB Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about ATOSB comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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