The Protein Atonal Homolog 7: A Promising Drug Target and Biomarker

Target Name: ATOH7

NCBI ID: G220202

ATOH7

The Protein Atonal Homolog 7: A Promising Drug Target and Biomarker

ATOH7, or Protein Atonal Homolog 7, is a gene that encodes a protein known to play a critical role in the regulation of various cellular processes. The protein is highly conserved across various species, which suggests its importance in cellular function. The encoded protein has been implicated in various cellular processes, including cell signaling, stress response, and neurodegeneration.

Recent studies have identified ATOH7 as a potential drug target and biomarker for various diseases, including neurodegenerative disorders, cancer, and cardiovascular diseases. This has led to increased interest in the research of ATOH7 and its potential applications in drug development.

Understanding the Protein Atonal Homolog 7 (ATOH7)

ATOH7 is a protein that belongs to the family of tonic proteins, which are involved in the regulation of cellular processes that are critical for the survival of the cell. The tonic proteins are a subset of the protein superfamily, which includes various proteins involved in various cellular processes, including stress response, cell signaling, and cytoskeletal organization.

The protein encoded by the ATOH7 gene is 11.1 kDa and contains 10 known protein domains, including a tonic domain, a catalytic domain, and a N-terminus. The tonic domain is the most well-studied, and it is involved in the regulation of various cellular processes, including cell signaling, stress response, and neurodegeneration.

The catalytic domain of ATOH7 is known to have a catalytic activity, which suggests its involvement in various cellular processes. The catalytic domain is also known to be involved in the regulation of cellular signaling pathways, including the TGF-β pathway.

The N-terminus of ATOH7 is involved in the protein-protein interaction and may play a role in the regulation of various cellular processes.

Potential Applications of ATOH7 as a Drug Target

The identification of ATOH7 as a potential drug target has led to increased interest in its potential applications in drug development. The protein is involved in various cellular processes that are critical for the survival of the cell, which makes it an attractive target for small molecules.

One of the potential applications of ATOH7 as a drug target is its involvement in neurodegenerative disorders. neurodegenerative disorders, such as Alzheimer's disease, Parkinson's disease, and Huntington's disease, are characterized by the progressive loss of brain cells that lead to the degenerative changes observed in the affected regions.

Studies have shown that the expression of ATOH7 is affected in various neurodegenerative disorders. For example, researchers have shown that the expression of ATOH7 is reduced in the brains of individuals with Alzheimer's disease compared to age-matched controls.

In addition to its involvement in neurodegenerative disorders, ATOH7 has also been shown to be involved in cancer. The protein is involved in the regulation of cell signaling pathways, which are critical for the development and progression of cancer.

ATOH7 has also been shown to be involved in cardiovascular diseases. The protein is involved in the regulation of various cellular processes that are critical for cardiovascular function, including blood pressure and cholesterol levels.

Potential Biomarkers for ATOH7

The identification of ATOH7 as a potential drug target has also led to increased interest in its potential as a biomarker for various diseases. The protein is involved in various cellular processes that are critical for the survival of the cell, which makes it an attractive target for biomarkers.

One of the potential biomarkers for

Protein Name: Atonal BHLH Transcription Factor 7

Functions: Transcription factor that binds to DNA at the consensus sequence 5'-CAG[GC]TG-3' (PubMed:31696227). Dimerization with TCF3 isoform E47 may be required in certain situations (PubMed:31696227). Binds to gene promoters and enhancer elements, and thereby regulates a transcriptional program of retinal ganglion cell (RGC) determinant genes (By similarity). Although the exact mechanism is not certain, retinal transcription regulation by ATOH7 has a role in RGC determination and survival, photoreceptor population development, targeting of RGC axons to the optic nerve and development of the retino-hypothalamic tract (By similarity). Binds to its own promoter and enhancer sequences, suggesting autoregulation of ATOH7 transcription (By similarity). Required for retinal circadian rhythm photoentrainment (By similarity). Plays a role in brainstem auditory signaling and binaural processing (By similarity)

The "ATOH7 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about ATOH7 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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