Unlocking the Potential of ATP13A3: A Drug Target and Biomarker for Polyamine Transport

Target Name: ATP13A3

NCBI ID: G79572

ATP13A3

Unlocking the Potential of ATP13A3: A Drug Target and Biomarker for Polyamine Transport

Introduction

Polyamines, such as inositol, uridine, and spermidine, play crucial roles in various cellular processes, including DNA replication, gene expression, and cell signaling. However, their levels often fluctuate, and imbalances in polyamine transport can lead to physiological and therapeutic issues. The polyamine-transporting ATPase 13A3 (ATP13A3) is a key enzyme that regulates polyamine levels and has been identified as a potential drug target and biomarker.

In this article, we will explore the structure and function of ATP13A3, its role in polyamine transport, and its potential as a drug target and biomarker.

Structure and Function of ATP13A3

ATP13A3 is a 27-kDa ATP-dependent polyamine transporter that is expressed in various tissues, including brain, heart, liver, and kidney. Its catalytic active site is located at the base of the alpha subunit, and it has a unique 尾 subunit that is responsible for the transport of spermidine and uridine monosaccharides.

ATP13A3 functions as a ATPase, using ATP energy to drive the transport of polyamines through its catalytic active site. The polyamines targeted for transport are held by specific amino acid side chains that interact with the ATPase active site. These interactions cause a conformational change that exposes the active site for the binding of ATP. The 尾 subunit is responsible for the binding of spermidine and uridine monosaccharides, while the alpha subunit is responsible for the overall ATP-dependent transport process.

ATP13A3 is a versatile enzyme that can be regulated by various mechanisms, including changes in its expression levels, which can affect its transport capacity. Additionally, its expression can be modulated by various small molecules, including drugs, which may make it an attractive target for drug development.

Potential Therapeutic Applications of ATP13A3

The deficiency of functional ATP13A3 has been implicated in various physiological and therapeutic issues. Imbalances in polyamine transport have been implicated in various neurological and psychiatric disorders, including Alzheimer's disease, Parkinson's disease, and depression.

In addition, disruptions in ATP13A3 function have also been implicated in various diseases, including cancer, where polyamine transport has been shown to play a role in tumor progression and the development of drug resistance.

Drugs that can modulate ATP13A3 function may have significant therapeutic applications. For example, inhibitors of ATP13A3 have been shown to be effective in treating various neurological and psychiatric disorders, including Alzheimer's disease, Parkinson's disease, and depression. Additionally, modulators of ATP13A3 function have also has been shown to be effective in treating cancer and other diseases.

Biomarkers for the Assessment of ATP13A3 Function

The reliable measurement of ATP13A3 function is critical for understanding the underlying mechanisms of its dysfunction and the effectiveness of potential therapeutic approaches. Several biomarkers have been identified that can be used to assess ATP13A3 function, including:

1. Polyamine levels: The levels of various polyamines, including inositol, uridine, and spermidine, can be used as biomarkers to assess ATP13A3 function. The levels of these polyamines can be affected by various factors, including changes in ATP13A3 function, which can lead to imbalances in their levels.
2.Transport capacity: The transport capacity of ATP13A3 can be

Protein Name: ATPase 13A3

Functions: ATP-driven pump involved in endocytosis-dependent polyamine transport. Uses ATP as an energy source to transfer polyamine precursor putrescine from the endosomal compartment to the cytosol

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