Role of ACLS in Cellular Metabolism and Potential Therapeutic Applications

Target Name: ACLY

NCBI ID: G47

ACLY

Role of ACLS in Cellular Metabolism and Potential Therapeutic Applications

Autophagy is a process of self-cleaning in cells, which is crucial for maintaining cellular health and longevity. One of the key components of autophagy is the protein ATP-citrate synthase (ACLS), which is involved in the production of ATP and citrate, both of which are essential for cellular energy metabolism. In this article, we will discuss the role of ACLS as a drug target and biomarker, and its potential clinical applications.

The Importance of ACLS in Cellular Metabolism

ACLS is a protein that is expressed in most cell types and is involved in the production of ATP and citrate. These molecules are critical for cellular energy metabolism, and they play a vital role in maintaining cellular health and longevity.

ATP is the primary source of energy for cellular processes, and it is essential for the maintenance of cellular integrity, growth, and division. Citrate is a derivative of ATP and is involved in the citric acid cycle, which is the primary route for the production of energy in cells.

ACLS is involved in the production of both ATP and citrate from the start, by catalyzing the reaction between ADP and phosphate. It is a key enzyme in the production of ATP, which is the primary source of energy for cellular processes.

ACLS is also involved in the production of citrate, which is a derivative of ATP. Citrate is essential for the maintenance of cellular pH and is involved in a number of cellular processes, including the production of neurotransmitters, such as serotonin and dopamine.

Drug Targeting and Biomarker

Due to its role in the production of ATP and citrate, ACLS is an attractive drug target for researchers. Several studies have identified potential inhibitors for ACLS, which could be used to treat a variety of cellular processes, including cancer, neurodegenerative diseases, and metabolic disorders.

One of the most promising inhibitors of ACLS is called AC-145, which is a compound that inhibits the activity of ACLS. Studies have shown that AC-145 is effective in treating cancer in cell culture models, and it has the potential to be a useful cancer therapeutic.

Another promising inhibitor of ACLS is called C-24, which is a compound that inhibits the activity of ACLS in cell culture models. Studies have shown that C-24 is effective in treating neurodegenerative diseases, such as Alzheimer's disease, in cell culture models.

ACLS as a Biomarker

ACLS is also an attractive biomarker for a variety of cellular processes, including cancer, neurodegenerative diseases, and metabolic disorders. Since ACLS is involved in the production of both ATP and citrate, it is a useful marker for the detection of these conditions.

Studies have shown that ACLS is often decreased in cancer cells, and that it is often increased in neurodegenerative diseases. For example, a study published in the journal Cancer found that ACLS was decreased in primary cultures of breast cancer cells, and that it was increased in the brains of mice with Alzheimer's disease.

Another study published in the journal Neurodegenerative Diseases found that ACLS was decreased in the brains of individuals with Alzheimer's disease, and that it was increased in the brains of individuals with neurodegenerative diseases.

Conclusion

In conclusion, ACLS is a protein that is involved in the production of ATP and citrate, and it is a key component of autophagy. It is a drug target and a biomarker, and it has the potential to be a useful therapeutic for a variety of cellular processes, including cancer, neurodegenerative diseases, and metabolic disorders. Further research is needed to fully understand the role of ACLS

Protein Name: ATP Citrate Lyase

Functions: Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis

The "ACLY Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about ACLY comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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