NOTCH3: A Target for Cancer Therapies (G4854)

Target Name: NOTCH3

NCBI ID: G4854

NOTCH3

NOTCH3: A Target for Cancer Therapies

NOTCH3 (Notch 3) is a transmembrane protein that is expressed in a variety of tissues, including neural, epithelial, and hematopoietic cells. It is a key regulator of cell-cell and cell-tissue interactions and has been implicated in a number of diseases , including cancer, neurodegenerative diseases, and autoimmune disorders.

In addition to its role in cell-cell and cell-tissue interactions, NOTCH3 is also involved in the regulation of cell fate and has been shown to play a role in the development and progression of cancer.

Given the importance of NOTCH3 in the regulation of cell-cell and cell-tissue interactions and its involvement in the development and progression of cancer, it is a potential drug target or biomarker for a variety of diseases.

One approach to targeting NOTCH3 is to use small molecules that can modulate its activity. These small molecules can be found in a variety of natural compounds, including fruits, vegetables, and herbs. For example, a compound found in the leaves of the berry tree , called NOTCH3-inhibitor A, has been shown to inhibit the activity of NOTCH3 and prevent it from regulating the development and progression of cancer.

Another approach to targeting NOTCH3 is to use antibodies that can specifically recognize and target it. These antibodies can be used to detect and measure the level of NOTCH3 in a variety of tissues and cells, allowing researchers to study its activity and function.

In addition to its potential as a drug target or biomarker, NOTCH3 is also a potential target for other therapies, such as cancer vaccines. Cancer vaccines can be used to stimulate an immune response in the body, which can be an effective way to treat cancer . By targeting NOTCH3, cancer vaccines can potentially be designed to inhibit its activity and prevent cancer cells from forming.

Overall, NOTCH3 is a complex protein that plays a critical role in the regulation of cell-cell and cell-tissue interactions and is involved in the development and progression of a variety of diseases. As such, it is a potential drug target or biomarker for a variety of therapies. Further research is needed to fully understand its role and potential as a therapeutic target.

Protein Name: Notch Receptor 3

Functions: Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination (PubMed:15350543). Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity)

The "NOTCH3 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about NOTCH3 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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