NOX4 Gene Encodes Protein Involved in ROS Production (G50507)

Target Name: NOX4

NCBI ID: G50507

NOX4

NOX4 Gene Encodes Protein Involved in ROS Production

NOX4, or NADPH oxidase 4, is a gene that encodes a protein involved in the production of reactive oxygen species (ROS) in the body. NADPH oxidase 4 is a key enzyme in the antioxidant response, which helps to protect cells from damage caused by ROS.

NOX4 is a transcript variant, which means that it has different variants or copies of the gene that are expressed in the body. One of these variants, known as NOX4-transcript variant 5, has been shown to have unique functions and features compared to the other variants.

The NADPH oxidase 4 gene is located on chromosome 19 at position 6.2 kb. It encodes a protein with a molecular weight of approximately 43 kDa. The protein has four known functions, including the production of NO2- from NADPH, the production of O2- from H2O2, the production of H2O from O2- and H+, and the production of O2- from NO.

NOX4 is a member of the NADPH oxidase (NOX) family, which includes a variety of enzymes involved in the production of ROS. These enzymes use different subunits to catalyze different aspects of the antioxidant response. NOX4 is one of the four known subunits of NOX4, which consists of a catalytic subunit, a regulatory subunit, and two subunits involved in the electron transport chain.

The NOX4 gene has been shown to have unique functions and features compared to the other variants. For example, studies have shown that NOX4-transcript variant 5 has a more stable catalytic activity than the other variants. This suggests that the variant may be more effective at catalyzing the production of ROS, making it a potential drug target or biomarker.

Another study has shown that NOX4-transcript variant 5 has unique expression patterns in different tissues and organs. This suggests that the variant may have different functions in different body systems, which could make it a valuable tool for drug development.

In conclusion, NOX4 is a gene that encodes a protein involved in the production of ROS. NOX4-transcript variant 5 is a unique variant that has been shown to have unique functions and features compared to the other variants. Further research is needed to fully understand the functions and potential uses of NOX4-transcript variant 5, including its potential as a drug target or biomarker.

Protein Name: NADPH Oxidase 4

Functions: Constitutive NADPH oxidase which generates superoxide intracellularly upon formation of a complex with CYBA/p22phox. Regulates signaling cascades probably through phosphatases inhibition. May function as an oxygen sensor regulating the KCNK3/TASK-1 potassium channel and HIF1A activity. May regulate insulin signaling cascade. May play a role in apoptosis, bone resorption and lipolysaccharide-mediated activation of NFKB. May produce superoxide in the nucleus and play a role in regulating gene expression upon cell stimulation. Isoform 3 is not functional. Isoform 5 and isoform 6 display reduced activity

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