NPHP3: A Potential Drug Target and Biomarker for Kidney Disease

Target Name: NPHP3

NCBI ID: G27031

NPHP3

NPHP3: A Potential Drug Target and Biomarker for Kidney Disease

Nephrocystin-3 (NPHP3) is a protein that is expressed in the urine and feces of individuals with kidney disease. It has been found to be expressed in lower levels than other proteins in the urine of individuals with minimal change disease, a type of kidney disease that is characterized by the loss of urine but not significant proteinuria. NPHP3 has also been found to be expressed in urine samples from individuals with more severe forms of kidney disease, such as focal segmental glomerulosclerosis (FSG) and diabetic nephropathy.

NPHP3 is a member of the cystatin family, a group of proteins that are involved in the regulation of proteinuria in the urine. Cystatin genes encode for proteins that can interact with specific cysteine residues on proteins to modulate their stability and facilitate their excretion in the urine. NPHP3 is a type of cystatin that is expressed in the urine and feces of individuals with kidney disease.

The exact function of NPHP3 is not yet fully understood, but it is thought to play a role in the regulation of proteinuria in the urine. Studies have shown that NPHP3 can interact with other proteins that are involved in the regulation of proteinuria, such as albumin and globulin. This suggests that NPHP3 may be involved in the competition for these proteins, which could lead to decreased levels of these proteins in the urine if NPHP3 is increased.

In addition to its potential role in the regulation of proteinuria, NPHP3 has also been found to be a potential biomarker for kidney disease. Studies have shown that individuals with higher levels of NPHP3 in their urine are more likely to have poorer kidney function and a higher risk of developing kidney disease. This suggests that NPHP3 may be a useful diagnostic marker for individuals with kidney disease.

While more research is needed to fully understand the role of NPHP3 in kidney disease, it is clear that NPHP3 is an important protein that is involved in the regulation of proteinuria and may be a potential drug target. Further studies are needed to determine the exact function of NPHP3 and its potential utility as a drug target.

Protein Name: Nephrocystin 3

Functions: Required for normal ciliary development and function. Inhibits disheveled-1-induced canonical Wnt-signaling activity and may also play a role in the control of non-canonical Wnt signaling which regulates planar cell polarity. Probably acts as a molecular switch between different Wnt signaling pathways. Required for proper convergent extension cell movements

The "NPHP3 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about NPHP3 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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