NPC1L1: A Protein Involved in Immune Response and Disease (G29881)

Target Name: NPC1L1

NCBI ID: G29881

NPC1L1

NPC1L1: A Protein Involved in Immune Response and Disease

NPC1L1 (N-protein C receptor 1-like 1) is a protein that is expressed in various cell types in the body. It is a member of the N-protein C receptor family, which is a protein that is involved in the regulation of cellular processes such as inflammation, DNA damage repair, and cell adhesion.

NPC1L1 is known for its role in the regulation of cellular responses to bacterial infection. It is expressed in many different cell types, including epithelial cells, macrophages, and dendritic cells. It is also expressed in the secretions of many different cell types, including cancer cells.

One of the functions of NPC1L1 is to regulate the production of pro-inflammatory cytokines, which are molecules that play a key role in the inflammatory response. Pro-inflammatory cytokines, such as TNF-alpha, IL-12, and IL-18, are important for the recruitment of immune cells to the site of infection, and for triggering an inflammatory response.

NPC1L1 is also involved in the regulation of the production of anti-inflammatory cytokines, which are molecules that work to counteract the pro-inflammatory response. Pro-inflammatory cytokines, such as IL-10 and IL-13, are important for the regulation of immune cell function, and for promoting the production of anti-inflammatory cytokines.

In addition to its role in regulating the production of pro-inflammatory and anti-inflammatory cytokines, NPC1L1 is also involved in the regulation of cellular processes such as cell adhesion, migration, and the association of immune cells with infected cells.

Given its role in the regulation of cellular processes that are important for the immune response, NPC1L1 is an attractive drug target for researchers. Many different approaches have been used to study the biology of NPC1L1, including cell-based assays, in vitro assays, and animal models of disease.

One of the potential benefits of targeting NPC1L1 is that it is a protein that is expressed in many different cell types, which makes it an attractive target for drugs that can act across different cell types. This can make it easier to identify the effects of a drug on a wide range of cell types, and to determine how a drug might be expected to impact different cell types.

Another potential benefit of targeting NPC1L1 is that it is involved in the regulation of important cellular processes that are involved in the development and progression of many different diseases. For example, NPC1L1 is involved in the regulation of the production of pro-inflammatory cytokines, which can contribute to the development of inflammatory diseases such as heart disease and cancer. It is also involved in the regulation of the production of anti-inflammatory cytokines, which can help to counteract the pro-inflammatory response and promote the resolution of inflammatory diseases.

In addition to its potential as a drug target, NPC1L1 is also an attractive biomarker for the diagnosis and assessment of disease. For example, NPC1L1 is often expressed in the secretions of cells that are involved in the development and progression of many different diseases, including cancer. This makes it a potential indicator of disease status, and can be used to track the progress of disease over time.

Overall, NPC1L1 is an interesting protein that is involved in the regulation of important cellular processes that are involved in the development and progression of many different diseases. As a drug target and biomarker, NPC1L1 is a promising target for the development of new therapies for a wide range of diseases.

Protein Name: NPC1 Like Intracellular Cholesterol Transporter 1

Functions: Plays a major role in cholesterol homeostasis (PubMed:22095670). Critical for the uptake of cholesterol across the plasma membrane of the intestinal enterocyte (PubMed:22095670). Involved in plant sterol absorption, it transports sitosterol, although at lower rates than cholesterol (By similarity). Is the direct molecular target of ezetimibe, a drug that inhibits cholesterol absorption and is approved for the treatment of hypercholesterolemia (PubMed:15928087). May have a function in the transport of multiple lipids and their homeostasis, thereby influencing lipid metabolism regulation (PubMed:15671032). May be involved in caveolin trafficking from the plasma membrane (By similarity). In addition, acts as a negative regulator of NPC2 and down-regulates its expression and secretion by inhibiting its maturation and accelerating its degradation (PubMed:22095670)

The "NPC1L1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about NPC1L1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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