UTP11: Key Component of Eukaryotic Cell's Ultracentral Transport System

Target Name: UTP11

NCBI ID: G51118

UTP11

UTP11: Key Component of Eukaryotic Cell's Ultracentral Transport System

UTP11 (Ultrasensitive Transport System 11) is a gene that encodes a protein known as UTP11, which is a key component of the ultracentral transport system in eukaryotic cells. The ultracentral transport system is responsible for transporting synthesized proteins to their final destination, including the endoplasmic reticulum for degradation or storage. UTP11 plays a crucial role in this process, as it enables the efficient transport of proteins across the endoplasmic reticulum.

UTP11 is a member of the UTP family, which includes proteins that are involved in the transport of various molecules across the endoplasmic reticulum, including proteins, nucleic acids, and small molecules. The UTP family is characterized by the presence of a single transmembrane domain and a nucleotide-binding oligomerization (NBO) domain, which is responsible for the protein's stability and interaction with other molecules.

UTP11 is expressed in most eukaryotic organisms, including humans, and has been implicated in various cellular processes, including protein transport, cell signaling, and cell survival. One of the most significant functions of UTP11 is its role in the transport of growth factors, such as Wnt, which are essential for the development and maintenance of tissues in the body.

In addition to its role in protein transport, UTP11 is also involved in the regulation of cellular signaling pathways. For example, studies have shown that UTP11 can interact with the protein kinase kinase (PKP) to regulate the activity of various cellular signaling pathways, including the T-cell signaling pathway and theApoptosis signaling pathway.

UTP11 is also involved in the regulation of cell survival, as it has been shown to play a role in the stress response of cells. Studies have shown that UTP11 can interact with the protein heat shock protein (Hsp) to protect cells from heat stress, and that its expression is regulated by various stress-responsive pathways, including the unfolded protein response (UPR) and the DNA damage response (DDR).

UTP11 is also a potential drug target in the treatment of various diseases. For example, studies have shown that UTP11 is involved in the transport of the protein p16INK4a, which is a known tumor suppressor gene that can be aberrantly expressed in various types of cancer. Therefore, inhibiting the activity of UTP11 has been shown to be a potential strategy for the treatment of cancer.

In addition to its potential therapeutic applications, UTP11 is also an attractive biomarker for the diagnosis and prognosis of various diseases. For example, studies have shown that the expression of UTP11 is regulated by various stress-responsive pathways, including the UPR and the DDR. Therefore, changes in the expression of UTP11 have been shown to be associated with various cellular stress responses, including cell death, inflammation, and fibrosis.

In conclusion, UTP11 is a gene that encodes a protein involved in the ultracentral transport system of eukaryotic cells. Its expression is regulated by various stress-responsive pathways, and it has been implicated in various cellular processes, including protein transport, cell signaling, and cell survival. In addition to its role in cellular processes, UTP11 is also a potential drug target and a biomarker for the diagnosis and prognosis of various diseases. Further research is needed to fully understand the functions of UTP11 and its potential as a therapeutic target.

Protein Name: UTP11 Small Subunit Processome Component

Functions: Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Involved in nucleolar processing of pre-18S ribosomal RNA

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