Target Name: RNF138
NCBI ID: G51444
Review Report on RNF138 Target / Biomarker Content of Review Report on RNF138 Target / Biomarker
RNF138
Other Name(s): E3 ubiquitin-protein ligase RNF138 | ring finger protein 138 | HSD-4 | RING finger protein 138 | E3 ubiquitin-protein ligase RNF138 (isoform 1) | Ring finger protein 138, transcript variant 1 | ring finger protein 138, E3 ubiquitin protein ligase | RN138_HUMAN | NLK-associated RING finger protein | RNF138 variant 1 | Nemo-like kinase-associated RING finger protein | RING-type E3 ubiquitin transferase RNF138 | STRIN | testicular tissue protein Li 165 | MGC8758 | NARF | nemo-like kinase associated ring finger protein | hNARF

Unveiling the Potential of RNF138 as a Drug Target and Biomarker for various diseases

Abstract:

RNF138, a member of the ENPP family, is a non-coding RNA molecule that plays a crucial role in the regulation of gene expression and cellular processes. The identification and characterization of RNA molecules like RNF138 are of great interest for the development of new drugs and biomarkers for various diseases. In this article, we provide an overview of RNF138, its functions, and its potential as a drug target and biomarker.

Introduction:

Rare Nuclear Factor (RNF) proteins are a family of non-coding RNAs that play a significant role in the regulation of gene expression and cellular processes. These proteins are named after their nuclear localization and are involved in various cellular processes such as DNA replication, transcription, and splicing etc. RNF138 is a member of the ENPP (Endoplasmic Reticulum-Nucleus Protein) family, which is characterized by the presence of a nucleotide-binding oligomerization domain (NBO), a conserved domain that plays a crucial role in the formation of RNA structures.

Expression and Localization:

RNA expression and localization are critical factors in the regulation of gene expression, and RNF138 is no exception. RNF138 is primarily expressed in the cytoplasm of human cells and has been shown to be located in the endoplasmic reticulum (ER) and the nuclear pore complex ( NPC), which are both important organelles involved in the transport of proteins to the cytoplasm and the ER, respectively. These localizations are important for the regulation of various cellular processes, including cell growth, apoptosis, and DNA replication.

Function and Potential as a Drug Target:

The functions of RNF138, as well as its potential as a drug target, are still being explored. Several studies have demonstrated that RNF138 plays a role in the regulation of cellular processes, including cell growth, apoptosis, and DNA replication. Additionally, studies have also shown that RNF138 can be targeted by small molecules, such as inhibitors, to inhibit its activity and prevent the progression of certain diseases.

One of the promising aspects of RNF138 is its potential as a drug target is its involvement in various diseases, including cancer, neurodegenerative diseases, and autoimmune diseases. Cancer, for example, is a disease that can be treated by targeting the regulation of gene expression , and RNF138 is involved in this process. Studies have shown that altered levels of RNF138 have been observed in various types of cancer, and that inhibitors of RNF138 have been shown to be effective in treating these diseases.

Another promising aspect of RNF138 is its role in neurodegenerative diseases, such as Alzheimer's and Parkinson's diseases. These diseases are characterized by the progressive loss of brain cells, and the regulation of gene expression is a crucial factor in their development. Studies have shown that RNF138 is involved in the regulation of neurodegenerative diseases and that inhibitors of RNF138 have been shown to be effective in treating these diseases.

In addition to its potential as a drug target, RNF138 has also been shown to be a potential biomarker for various diseases. The regulation of gene expression is a critical factor in the development and progression of many diseases, including cancer, neurodegenerative diseases, and autoimmune diseases. Therefore, the regulation of gene expression by RNF138 can be used as a biomarker for these diseases. Studies have shown that altered levels of RNF138 have

Protein Name: Ring Finger Protein 138

Functions: E3 ubiquitin-protein ligase involved in DNA damage response by promoting DNA resection and homologous recombination (PubMed:26502055, PubMed:26502057). Recruited to sites of double-strand breaks following DNA damage and specifically promotes double-strand break repair via homologous recombination (PubMed:26502055, PubMed:26502057). Two different, non-exclusive, mechanisms have been proposed. According to a report, regulates the choice of double-strand break repair by favoring homologous recombination over non-homologous end joining (NHEJ): acts by mediating ubiquitination of XRCC5/Ku80, leading to remove the Ku complex from DNA breaks, thereby promoting homologous recombination (PubMed:26502055). According to another report, cooperates with UBE2Ds E2 ubiquitin ligases (UBE2D1, UBE2D2, UBE2D3 or UBE2D4) to promote homologous recombination by mediating ubiquitination of RBBP8/CtIP (PubMed:26502057). Together with NLK, involved in the ubiquitination and degradation of TCF/LEF (PubMed:16714285). Also exhibits auto-ubiquitination activity in combination with UBE2K (PubMed:16714285). May act as a negative regulator in the Wnt/beta-catenin-mediated signaling pathway (PubMed:16714285)

The "RNF138 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about RNF138 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets

RNF138P1 | RNF139 | RNF139-DT | RNF14 | RNF141 | RNF144A | RNF144B | RNF145 | RNF146 | RNF148 | RNF149 | RNF150 | RNF151 | RNF152 | RNF157 | RNF157-AS1 | RNF165 | RNF166 | RNF167 | RNF168 | RNF169 | RNF17 | RNF170 | RNF175 | RNF180 | RNF181 | RNF182 | RNF183 | RNF185 | RNF186 | RNF187 | RNF19A | RNF19B | RNF2 | RNF20 | RNF207 | RNF208 | RNF212 | RNF212B | RNF213 | RNF213-AS1 | RNF214 | RNF215 | RNF216 | RNF216-IT1 | RNF216P1 | RNF217 | RNF217-AS1 | RNF220 | RNF222 | RNF224 | RNF225 | RNF227 | RNF24 | RNF25 | RNF26 | RNF31 | RNF32 | RNF32-DT | RNF34 | RNF38 | RNF39 | RNF4 | RNF40 | RNF41 | RNF43 | RNF44 | RNF5 | RNF5P1 | RNF6 | RNF7 | RNF7P1 | RNF8 | RNFT1 | RNFT2 | RNGTT | RNH1 | RNLS | RNMT | RNPC3 | RNPC3-DT | RNPEP | RNPEPL1 | RNPS1 | RNPS1P1 | RNR1 | RNR2 | RNU1-1 | RNU1-100P | RNU1-108P | RNU1-11P | RNU1-134P | RNU1-18P | RNU1-3 | RNU1-31P | RNU1-32P | RNU1-36P | RNU1-38P | RNU1-4 | RNU1-42P