PHB1: A Key Protein in Male Reproductive System (G5245)

Target Name: PHB1

NCBI ID: G5245

PHB1

PHB1: A Key Protein in Male Reproductive System

PHB1, also known as epididymis luminal protein 215, is a protein that is expressed in the testes and other male reproductive organs. It is a member of the Luminal Protein family, which is a group of transmembrane proteins that are involved in various physiological processes in the body, including reproduction and development.

PHB1 is one of the key proteins involved in the development and maintenance of the vas deferens, which are the specialized blood vessels that carry sperm from the testes to the prostate gland. The vas deferens are lined with PHB1, which helps to keep the tissue secure and protected from the surrounding environment.

In addition to its role in the development and maintenance of the vas deferens, PHB1 is also involved in the regulation of various signaling pathways that are involved in male reproductive function. For example, it has been shown to be involved in the regulation of androgens, which are sex hormones that are involved in male reproductive development and function.

PHB1 is also expressed in the seminal vesicles, which are the small structures that produce and store sperm. It is thought to play a role in the production and maturation of sperm, as well as the overall health and function of the testes.

Given its involvement in the development and maintenance of the vas deferens, PHB1 is a potential drug target for a variety of reproductive health conditions. For example, testicular cancer is a common diagnosis in males, and it is often associated with poor prognosis and quality of life. Improving the function of PHB1 and other genes involved in reproductive function may have the potential to improve outcomes in testicular cancer and other male reproductive health conditions.

In addition to its potential as a drug target, PHB1 is also a potential biomarker for the diagnosis and monitoring of male reproductive health. For example, measuring the expression of PHB1 in testicular tissue or seminal vesicles could be used as a marker for the health and function of the testes, and may be able to provide valuable information about the overall health of a male.

Overall, PHB1 is a complex and important protein that is involved in various physiological processes in the male reproductive system. Its potential as a drug target and biomarker make it an attractive target for research in the field of reproductive health. Further studies are needed to fully understand the role of PHB1 and its potential as a therapy for male reproductive health conditions.

Protein Name: Prohibitin 1

Functions: Protein with pleiotropic attributes mediated in a cell-compartment- and tissue-specific manner, which include the plasma membrane-associated cell signaling functions, mitochondrial chaperone, and transcriptional co-regulator of transcription factors in the nucleus (PubMed:11302691, PubMed:20959514, PubMed:28017329, PubMed:31522117). Plays a role in adipose tissue and glucose homeostasis in a sex-specific manner (By similarity). Contributes to pulmonary vascular remodeling by accelerating proliferation of pulmonary arterial smooth muscle cells (By similarity)

The "PHB1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about PHB1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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