Unlocking the Potential of ATP6V0C as a Drug Target and Biomarker for Vacuolar H+ ATPase Proton Channel Subunit

Target Name: ATP6V0C

NCBI ID: G527

ATP6V0C

Unlocking the Potential of ATP6V0C as a Drug Target and Biomarker for Vacuolar H+ ATPase Proton Channel Subunit

ATP6V0C, also known as V-type ATPase proton channel subunit, is a protein that plays a crucial role in various cellular processes, including acidification and buffering of intracellular pH (pH). It is a subunit of the ATP6V0 complex, which is responsible for generating ATP via the production of high-energy ATP fromADP. This subunit is found in different cell types, including epithelial, endothelial, and muscle cells, and is involved in the regulation of intracellular pH, which is critical for maintaining the stability of various cellular processes and is closely associated with various diseases, including diabetes, hypertension, and neurodegenerative disorders.

Recent studies have identified ATP6V0C as a potential drug target and biomarker for various diseases. In this article, we will explore the recent findings on ATP6V0C and its potential as a drug target and biomarker.

The Role of ATP6V0C in Acidification and Buffering of Intracellular pH

ATP6V0C is a key protein that is involved in the regulation of acidification and buffering of intracellular pH. This subunit is responsible for generating ATP via the production of high-energy ATP fromADP, which is then used to maintain the pH of the intracellular environment.

ATP6V0C plays a crucial role in the regulation of acidification and buffering of intracellular pH because it is involved in the production of ATP, which is the primary source of energy for the cells that maintain pH homeostasis. The production of ATP from ADP via the ATP6V0C subunit generates high-energy ATP that can be used to maintain the pH of the intracellular environment.

ATP6V0C is also involved in the regulation of the production of other molecules that are involved in acidification and buffering of intracellular pH. For instance, ATP6V0C has been shown to be involved in the regulation of the production of H+ ions, which are essential for the production of ATP via the citric acid cycle. Additionally, ATP6V0C has been shown to be involved in the regulation of the production of buffer substances, such as caseins and histidine, which are involved in maintaining the pH of the intracellular environment.

Potential Drug Targets and Biomarkers for ATP6V0C

Recent studies have identified ATP6V0C as a potential drug target and biomarker for various diseases. The high-energy ATP produced by ATP6V0C can be used to treat various metabolic disorders, including diabetes.

One of the promising strategies to target ATP6V0C is to inhibit its function by introducing mutations in the subunit that alter its stability or function. This can be done by using small molecules, such as inhibitors, or by using antibodies to block the function of ATP6V0C.

Another approach to target ATP6V0C is to use drugs that specifically target its activity. For example, inhibitors of the ATP6V0C subunit have been shown to be effective in treating various metabolic disorders, including diabetes. These inhibitors work by blocking the function of ATP6V0C and preventing it from generating ATP, which is essential for the treatment of diabetes.

Biomarkers for ATP6V0C

ATP6V0C is involved in various cellular processes, including acidification and buffering of intracellular pH, which makes it an attractive biomarker for various diseases. Several biomarkers have been shown to be involved in the regulation of ATP6V0C, including:

1.

Protein Name: ATPase H+ Transporting V0 Subunit C

Functions: Proton-conducting pore forming subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:33065002). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity)

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The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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