UBA6: A Potential Drug Target and Biomarker (G55236)

Target Name: UBA6

NCBI ID: G55236

UBA6

UBA6: A Potential Drug Target and Biomarker

Ubiquitin like modifier activating enzyme (UBA) 6 is a protein that plays a crucial role in cellular signaling pathways. UBA6 is a member of the UBA family of proteins, which are known for their ability to modify and activate ubiquitin, a protein that plays a central role in the immune and signaling systems. Mutations in UBA6 have been linked to various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. As a result, UBA6 has emerged as a promising drug target and biomarker for a variety of diseases.

The UBA6 protein is composed of 21 amino acid residues and has a calculated molecular weight of 23 kDa. It is a 126 amino acid long protein that is expressed in a variety of tissues, including the brain, heart, liver, and gastrointestinal tract. UBA6 is primarily localized to the endoplasmic reticulum (ER) and is involved in the modulation of several cellular signaling pathways.

One of the key functions of UBA6 is its ability to activate ubiquitin. Ubiquitin is a large protein that is involved in a wide range of cellular signaling pathways, including cell division, apoptosis, and inflammation. It can be modified and activated by several enzymes, including UBA6. The activated form of ubiquitin can then interact with various target proteins and influence their stability and activity.

UBA6 has been shown to play a role in several cellular signaling pathways, including the regulation of cell cycle progression, apoptosis, and the immune response. For example, studies have shown that UBA6 can influence the stability of the protein encoded by the CDK2 gene, which is involved in cell cycle progression. Additionally, UBA6 has been shown to play a role in the regulation of cell apoptosis, as well as in the development of neurodegenerative diseases.

Another function of UBA6 is its ability to modulate the activity of several enzymes involved in the immune response. UBA6 has been shown to interact with the protein encoded by the ITAM gene, which is involved in the regulation of ITAM-associated signaling pathways. These interactions have been shown to influence the activity of ITAM-associated enzymes and the regulation of cellular signaling pathways involved in cell death, inflammation, and cancer.

In addition to its role in cellular signaling pathways, UBA6 has also been shown to play a role in the regulation of protein stability and interactions. Studies have shown that UBA6 can interact with several proteins, including the protein encoded by the FBN1 gene. These interactions have been shown to influence the stability and activity of FBN1 and may play a role in the regulation of protein interactions and signaling pathways.

As a potential drug target, UBA6 has been shown to have a variety of therapeutic potential in a variety of diseases. For example, studies have shown that UBA6 mutations are associated with the development of neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. Additionally, UBA6 has been shown to be involved in the regulation of the immune response, which may play a role in the development of autoimmune diseases.

In addition to its potential therapeutic uses, UBA6 has also been shown to be a potential biomarker for several diseases. For example, studies have shown that UBA6 levels are elevated in the brains of individuals with Alzheimer's disease, which may be an indicator of the disease. Additionally, UBA6 has been shown to be involved in the regulation of cellular signaling pathways, which may be a potential biomarker for the development of cancer.

Overall, UBA6 is a protein that has a variety of functions in cellular signaling pathways, including the regulation of cell cycle progression, apoptosis, and the immune response. Its ability to

Protein Name: Ubiquitin Like Modifier Activating Enzyme 6

Functions: Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Specific for ubiquitin, does not activate ubiquitin-like peptides. Differs from UBE1 in its specificity for substrate E2 charging. Does not charge cell cycle E2s, such as CDC34. Essential for embryonic development. Required for UBD/FAT10 conjugation. Isoform 2 may play a key role in ubiquitin system and may influence spermatogenesis and male fertility

The "UBA6 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about UBA6 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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