PRKAR2A: Key Regulator of Cell Cycle and Disease (G5576)

Target Name: PRKAR2A

NCBI ID: G5576

PRKAR2A

PRKAR2A: Key Regulator of Cell Cycle and Disease

PRKAR2A (padding-remodeling protein 2A) is a protein that is expressed in various tissues throughout the body. It is a key regulator of the cell cycle, and is involved in the regulation of cell growth, differentiation, and the apoptosis process. PRKAR2A has also been shown to play a role in the development and progression of various diseases, including cancer. As a result, PRKAR2A has become a focus of interest for researchers and pharmaceutical companies, who are working to develop drugs that target this protein.

The protein encoded by the PRKAR2A gene is a 21-kDa protein that is expressed in a variety of tissues, including muscle, heart, brain, and cancer. It is composed of a unique catalytic domain and a long amino acid tail that is involved in its stability and regulation of activity. PRKAR2A is regulated by various cellular factors, including the cell cycle kinase A-TG1, which can induce its phosphorylation and subsequent translocation to the endoplasmic reticulum.

One of the most significant functions of PRKAR2A is its role in regulating the cell cycle. It is a key regulator of the G1 phase, which is the stage of cell growth and preparation for cell division. During the G1 phase, PRKAR2A helps to ensure that cells enter the S phase, where DNA replication and gene expression can occur. Additionally, PRKAR2A is involved in the regulation of the G2 phase, which is the stage of cell preparation for cell division. During the G2 phase, PRKAR2A helps to ensure that cells have enough copies of their DNA and RNA prepared for cell division.

In addition to its role in regulating the cell cycle, PRKAR2A is also involved in the regulation of cell growth and differentiation. It is a key regulator of the Wnt signaling pathway, which is involved in the regulation of cell growth and development. PRKAR2A helps to ensure that cells receive the right level of Wnt signaling, which can induce the formation of new tissues and organs during development.

PRKAR2A is also involved in the regulation of the apoptosis process. Apoptosis is a natural process that helps to remove damaged or dysfunctional cells from the body. PRKAR2A is involved in the regulation of apoptosis, which is regulated by various cellular factors, including the production of reactive oxygen species (ROS). ROS can cause damage to cellular components and contribute to the development of oxidative stress and age-related diseases. PRKAR2A helps to regulate the production of ROS and thereby protect cells from the harmful effects of ROS.

PRKAR2A has also been shown to play a role in the development and progression of various diseases, including cancer. For example, studies have shown that PRKAR2A is involved in the regulation of the growth and survival of cancer cells. In addition, PRKAR2A has also been shown to play a role in the regulation of angiogenesis, which is the process by which new blood vessels are formed in the body. The regulation of angiogenesis is important for the development of many diseases, including cancer.

As a result of its involvement in so many cellular processes, PRKAR2A has become a focus of interest for researchers and pharmaceutical companies. Many drugs that are currently in use target PRKAR2A, and studies are being conducted to determine the effectiveness of these drugs in the treatment of various diseases. For example, studies have shown that inhibiting PRKAR2A activity can be an effective way to treat cancer, including breast and ovarian cancers. Additionally, drugs that target PRKAR2A have also been shown to be effective in treating other diseases, including heart disease and neurological disorders.

In conclusion, PRKAR2A is a protein that is involved in a variety of cellular processes throughout the body. Its regulation of the

Protein Name: Protein Kinase CAMP-dependent Type II Regulatory Subunit Alpha

Functions: Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase

The "PRKAR2A Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about PRKAR2A comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets