SLC17A7: A Brain-specific Na(+)-Dependent Inorganic Phosphate Cotransporter

Target Name: SLC17A7

NCBI ID: G57030

SLC17A7

Other Name(s): Brain-specific Na(+)-dependent inorganic phosphate cotransporter | brain-specific Na-dependent inorganic phosphate cotransporter | Solute carrier family 17 member 7 | Vesicular glutamate transporter 1 | solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7 | VGLU1_HUMAN | brain-specific Na(+)-dependent inorganic phosphate cotransporter | solute carrier family 17 (vesicular glutamate transporter), member 7 | Solute carrier family 17, member 7 | solute carrier family 17 member 7 | VGluT1 | Brain-specific Na-dependent inorganic phosphate cotransporter | VGLUT1 | BNPI

SLC17A7: A Brain-specific Na(+)-Dependent Inorganic Phosphate Cotransporter

Sodium channels are essential for the proper functioning of the nervous system, and their regulation is critical for maintaining the electrical properties of the brain. The sodium channels are also involved in the intracellular signaling cascade, as they play a crucial role in the rapid and efficient transmission of signals within the nervous system. The brain is the most demanding organ in the body, and it requires a constant supply of nutrients and waste removal to maintain its functions. One of the essential ions for the brain is inorganic phosphate (IP), which plays a crucial role in various cellular processes, including but not limited to cell signaling, muscle contractions, and DNA replication. The brain is also the primary site of IP synthesis, and its levels are regulated by multiple factors, including ion channels, enzymes, and signaling pathways.

SLC17A7, a member of the Na(+)-dependent inorganic phosphate cotransporter family, is an essential protein for the brain that plays a crucial role in the regulation of IP synthesis and IP homeostasis. SLC17A7 is expressed in various tissues and cells of the brain, including neurons, astrocytes, and glial cells. It is involved in the transmembrane transport of IP across the endogenous membrane of these cells, and it is also involved in the regulation of IP levels within the cells.

SLC17A7 function

SLC17A7 is a member of the Na(+)-dependent inorganic phosphate cotransporter family, which includes other proteins that are involved in the regulation of IP synthesis and IP homeostasis, including SLC17A2, SLC17A3, and SLC17A6. These proteins are characterized by the presence of a unique transmembrane domain, which is responsible for the regulation of IP levels and the maintenance of IP homeostasis.

SLC17A7 is involved in the transmembrane transport of IP across the endogenous membrane of its cells. IP is an essential ion for the brain, and its levels are regulated by multiple factors, including sodium channels, enzymes, and signaling pathways. SLC17A7 is involved in the regulation of IP levels by controlling the transport of IP across the endogenous membrane of its cells. This is done by its transmembrane domain, which is responsible for the regulation of IP levels and the maintenance of IP homeostasis.

SLC17A7 is also involved in the regulation of IP levels within the cells. IP levels are regulated by various factors, including the activity of enzymes that are involved in IP synthesis and IP homeostasis. SLC17A7 is involved in the regulation of these enzymes by controlling the transport of IP across the endogenous membrane of its cells. This is done by its transmembrane domain, which is responsible for the regulation of IP levels and the maintenance of IP homeostasis.

Drug targeting

SLC17A7 is a potential drug target for various neurological and psychiatric disorders, including epilepsy, schizophrenia, and Alzheimer's disease. The regulation of IP levels and the maintenance of IP homeostasis are critical for the proper functioning of the brain, and alterations in IP levels can have a significant impact on brain function. SLC17A7 is a promising drug target because it is involved in the regulation of IP levels and its dysfunction has been implicated in various neurological and psychiatric disorders.

Conclusion

SLC17A7 is a protein that is involved in the regulation of inorganic phosphate (IP) levels and its dysfunction has been implicated in various neurological and psychiatric disorders. Its transmembrane domain, which is responsible for the regulation of IP levels and the maintenance of IP homeostasis, makes it a promising drug target for the treatment of these disorders. Further research is needed to fully understand the role of SLC17A7 in IP regulation and its potential as a drug

Protein Name: Solute Carrier Family 17 Member 7

Functions: Multifunctional transporter that transports L-glutamate as well as multiple ions such as chloride, proton, potassium, sodium and phosphate (PubMed:10820226). At the synaptic vesicle membrane, mainly functions as an uniporter which transports preferentially L-glutamate but also phosphate from the cytoplasm into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells (By similarity). The L-glutamate or phosphate uniporter activity is electrogenic and is driven by the proton electrochemical gradient, mainly by the electrical gradient established by the vacuolar H(+)-ATPase across the synaptic vesicle membrane (By similarity). In addition, functions as a chloride channel that allows a chloride permeation through the synaptic vesicle membrane that affects the proton electrochemical gradient and promotes synaptic vesicles acidification (By similarity). Moreover, may function as a K(+)/H(+) antiport allowing to maintain the electrical gradient and to decrease chemical gradient and therefore sustain vesicular glutamate uptake (By similarity). The vesicular K(+)/H(+) antiport activity is electroneutral (By similarity). At the plasma membrane, following exocytosis, functions as a symporter of Na(+) and phosphate from the extracellular space to the cytoplasm allowing synaptic phosphate homeostasis regulation (PubMed:10820226). The symporter activity is driven by an inside negative membrane potential and is electrogenic (By similarity). Is necessary for synaptic signaling of visual-evoked responses from photoreceptors (By similarity)

The "SLC17A7 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about SLC17A7 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets