CADM3: A Promising Drug Target and Biomarker for Neurodegenerative Disorders

Target Name: CADM3

NCBI ID: G57863

CADM3

CADM3: A Promising Drug Target and Biomarker for Neurodegenerative Disorders

Abstract:

CADM3, or synaptic cell adhesion molecule 3, is a protein that plays a crucial role in the development and progression of neurodegenerative disorders. Our study provides a comprehensive overview of CADM3, its functions, and its potential as a drug target and biomarker. The analysis covers the current research on CADM3's role in neurodegenerative diseases, its potential as a drug target, and its potential as a biomarker for diagnosing and monitoring these disorders.

Introduction:

Neurodegenerative disorders are a group of progressive diseases that affect the nervous system, including Alzheimer's disease, Parkinson's disease, Huntington's disease, and other conditions. These disorders are characterized by the progressive loss of neural cells and the damage to neural circuits that support brain function. The development and progression of these disorders are often accompanied by the accumulation of misfolded proteins, including CADM3, in the brain.

CADM3: Structure and Function

CADM3 is a transmembrane protein that belongs to the cadherin family. It is expressed in a variety of tissues and cells, including brain, heart, and pancreas. CADM3 is involved in cell-cell adhesion, as well as in the regulation of cell proliferation and differentiation.

One of the most significant functions of CADM3 is its role in the regulation of synaptic plasticity, which is the ability of the nervous system to change and adapt in response to experience. CADM3 is involved in the formation of synaptic plasticity-related memory traces, which are critical for the formation of long-term memories.

In addition to its role in synaptic plasticity, CADM3 is also involved in the regulation of neurotransmitter release and the modulation of pain perception.

Potential as a Drug Target:

CADM3 has been identified as a potential drug target for neurodegenerative disorders due to its involvement in multiple cellular processes that are important for the development and progression of these disorders.

One of the key reasons for CADM3's potential as a drug target is its involvement in the regulation of synaptic plasticity, which is a critical factor in the development of many neurodegenerative disorders. By targeting CADM3, researchers may be able to improve synaptic plasticity and reduce the symptoms of neurodegenerative disorders.

Another potential mechanism by which CADM3 may be targeted is its role in the regulation of pain perception. CADM3 has been shown to play a role in the modulation of pain sensitivity, and may be a potential drug target for pain relief in neurodegenerative disorders.

Potential as a Biomarker:

CADM3 may also be used as a biomarker for the diagnosis and monitoring of neurodegenerative disorders. The misfolded proteins that accumulate in the brain in these disorders, including CADM3, can be detected using biomarkers that are specific for these proteins, such as CADM3-containing assays.

These biomarkers can be used to diagnose neurodegenerative disorders at an early stage, when treatment is most effective. They can also be used to monitor the progression of these disorders and the effectiveness of different treatments.

Conclusion:

In conclusion, CADM3 is a protein that plays a crucial role in the development and progression of neurodegenerative disorders. Its functions in cell-cell adhesion, synaptic plasticity, and neurotransmitter release make it an attractive target for drug development. The potential of CADM3 as a drug and biomarker for neurodegenerative disorders is further supported by its involvement in multiple cellular processes that are important for brain function. Further research is needed to fully understand the role of CADM3 in neurodegenerative disorders and to develop effective treatments.

Protein Name: Cell Adhesion Molecule 3

Functions: Involved in the cell-cell adhesion. Has both calcium-independent homophilic cell-cell adhesion activity and calcium-independent heterophilic cell-cell adhesion activity with IGSF4, NECTIN1 and NECTIN3. Interaction with EPB41L1 may regulate structure or function of cell-cell junctions (By similarity)

The "CADM3 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about CADM3 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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