Calcocoo2: A Calcium-Binding and Coiled-Coil Domain-Containing Protein in Cancer and Neurodegenerative Diseases

Target Name: CALCOCO2

NCBI ID: G10241

CALCOCO2

Calcocoo2: A Calcium-Binding and Coiled-Coil Domain-Containing Protein in Cancer and Neurodegenerative Diseases

Calcocoo2, also known as calcium-binding and coiled-coil domain-containing protein 2 (isoform 1), is a unique protein that has been identified in various organisms, including bacteria, yeast, and eukaryotes. Its primary function is to regulate calcium homeostasis, which is crucial for various cellular processes, including muscle contractions, nerve signaling, and cell signaling pathways. In addition to its role in calcium homeostasis, Calcocoo2 has also been shown to play a significant role in cellular signaling, which may lead to its potential as a drug target or biomarker.

Molecular Structure and Function

The protein Calcocoo2 is characterized by a unique domains: a calcification domain, a coiled-coil domain, and a N-terminal domain. The calcification domain is responsible for the production of calcified tissues, such as bone and cartilage. The coiled-coil domain is responsible for the protein's stability and functions as a scaffold. The N-terminal domain contains various functional domains, including a tyrosine kinase domain, a GFP-labeled domain, and a domain responsible for interaction with calcium ions.

Calcocoo2 is involved in a wide range of cellular processes that require calcium homeostasis. One of its primary functions is to regulate the levels of calcium ions in the cytosol, which is the space outside the cell nucleus. Calcocoo2 has been shown to regulate the activity of the calcium-sensitive protein Parp, which is involved in DNA repair and cell survival. In addition, Calcocoo2 has been shown to interact with the transcription factor p21, which plays a role in cell growth, apoptosis, and cycle progression.

In addition to its role in calcium homeostasis, Calcocoo2 has also been shown to play a significant role in cellular signaling. Its coiled-coil domain has been shown to interact with various protein partners, including the protein Fyn, which is involved in cell signaling pathways. In addition, Calcocoo2 has been shown to interact with the protein Phospho-ABC, which is involved in acid-base balance and buffering.

Calcocoo2 has also been shown to play a role in the regulation of cellular processes that are relevant to neurodegenerative diseases. Its N-terminal domain has been shown to interact with the protein TDP-4, which is involved in the regulation of dopamine release from neurons. In addition, Calcocoo2 has been shown to interact with the protein Calbindin, which is involved in the detection of neuronal loss in neurodegenerative diseases.

Potential Therapeutic Applications

The potential therapeutic applications of Calcocoo2 are vast and varied. One of its primary functions is to regulate calcium homeostasis, which is crucial for various cellular processes. As a result, Calcocoo2 may be a useful target for therapies that are aimed at modulating calcium ion levels in the body. For example, therapeutic agents that are designed to inhibit the activity of Parp or Fyn, which are involved in the regulation of calcium homeostasis, may be effective in treating various diseases, including cancer and neurodegenerative diseases.

In addition to its potential as a therapeutic target, Calcocoo2 may also be used as a biomarker for various diseases. Its ability to regulate calcium homeostasis and its involvement in cellular signaling pathways make it an attractive candidate for a variety of diagnostic tests. For example, the levels of Calcocoo2 in cancer cells may be used as a marker for the

Protein Name: Calcium Binding And Coiled-coil Domain 2

Functions: Xenophagy-specific receptor required for autophagy-mediated intracellular bacteria degradation. Acts as an effector protein of galectin-sensed membrane damage that restricts the proliferation of infecting pathogens such as Salmonella typhimurium upon entry into the cytosol by targeting LGALS8-associated bacteria for autophagy (PubMed:22246324). Initially orchestrates bacteria targeting to autophagosomes and subsequently ensures pathogen degradation by regulating pathogen-containing autophagosome maturation (PubMed:23022382, PubMed:25771791). Bacteria targeting to autophagosomes relies on its interaction with MAP1LC3A, MAP1LC3B and/or GABARAPL2, whereas regulation of pathogen-containing autophagosome maturation requires the interaction with MAP3LC3C (PubMed:23022382, PubMed:25771791). May play a role in ruffle formation and actin cytoskeleton organization and seems to negatively regulate constitutive secretion (PubMed:17635994)

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•   expression level;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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