CADPS2: A Potential Drug Target and Biomarker for Secretion in Ca2+-Dependent Proteins

Target Name: CADPS2

NCBI ID: G93664

CADPS2

CADPS2: A Potential Drug Target and Biomarker for Secretion in Ca2+-Dependent Proteins

Abstract:
CADPS2 (Ca2+-dependent activator protein for secretion 2) is a protein that has been identified as a potential drug target and biomarker for secretion in Ca2+-dependent proteins. It is a member of the Ca2+-dependent translocation (Ca2+-AT) protein family , which is involved in the regulation of intracellular calcium (Ca2+) levels. The Ca2+-AT proteins play a crucial role in the regulation of various cellular processes, including intracellular signaling, neurotransmission, and secretion.

CADPS2 is expressed in a variety of tissues and cells, including muscle, heart, brain, and pancreas, and has been shown to play a role in the regulation of secretion in these tissues. It is a 21-kDa protein that consists of an N -terminal calbindin-like domain, a catalytic alpha-helix, and a C-terminal T-loop. The N-terminal domain is responsible for the calbindin-like activity, while the alpha-helical region is involved in the regulation of the protein's stability.

The Ca2+-AT proteins play a crucial role in the regulation of intracellular Ca2+ levels, as high levels of Ca2+ can cause various cellular signaling pathways to be disrupted. CADPS2 is known to regulate the activity of several other Ca2+-AT proteins, including the neurotransmitter -gated chloride channel (Cl- channel), the sodium channels, and the Ca2+-ATPase.

One of the most significant functions of CADPS2 is its role in the regulation of secretion. CADPS2 is involved in the formation of the secretory granule in epithelial cells, which is the site of protein secretion. It is known to interact with the transmembrane protein Skypin, which is involved in the regulation of secretion in epithelial cells. Skypin is a negative regulator of the Ca2+-ATPase, which is responsible for the release of Ca2+ from the endoplasmic reticulum (ER) and the regulation of Ca2+ levels in the cytosol.

CADPS2 is also involved in the regulation of cell signaling pathways that are dependent on Ca2+. It has been shown to interact with several other proteins involved in intracellular signaling, including the transcription factor p300 and the protein kinase A尾1. of the cytosolic Ca2+ levels, which are critical for the regulation of various cellular processes, including muscle contractions, nerve impulse conduction, and blood pressure.

In conclusion, CADPS2 is a protein that plays a crucial role in the regulation of secretion in Ca2+-dependent proteins. Its function as a potential drug target and biomarker makes it an attractive target for future research. Further studies are needed to fully understand the role of CADPS2 in the regulation of secretion and to determine its potential as a drug.

Protein Name: Calcium Dependent Secretion Activator 2

Functions: Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. Regulates neurotrophin release from granule cells leading to regulate cell differentiation and survival during cerebellar development. May specifically mediate the Ca(2+)-dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles (By similarity)

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•   general information;
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•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
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•   advantages and risks of development, etc.
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