CAVIN4: A Potential Drug Target and Biomarker for Cancer (G347273)

Target Name: CAVIN4

NCBI ID: G347273

CAVIN4

CAVIN4: A Potential Drug Target and Biomarker for Cancer

CAVIN4 (CAVN4_HUMAN) is a gene that encodes a protein known as CAVIN4. The CAVIN4 protein is a key regulator of the blood-brain barrier, which is a critical barrier that separates the brain from the surrounding blood vessels. The blood-brain barrier is essential for maintaining the health and function of the brain, as it filters out harmful substances and ensures the delivery of essential nutrients. However, the blood-brain barrier can also allow cancer cells to enter the brain and contribute to the development and progression of tumors.

Recent studies have identified CAVIN4 as a potential drug target and biomarker for cancer. The CAVIN4 protein has been shown to play a role in the development and progression of various types of cancer, including brain tumors. By targeting the CAVIN4 protein, researchers may be able to develop new treatments for these deadly diseases.

The Role of the CAVIN4 Protein in Cancer

Several studies have demonstrated that the CAVIN4 protein is involved in the development and progression of various types of cancer. For example, one study published in the journal \"Oncology Reports\" found that high levels of CAVIN4 were associated with poor prognosis in patients with colorectal cancer. The researchers suggested that targeting the CAVIN4 protein may be a promising new approach to treating this type of cancer.

Another study published in the journal \"Molecular Cancer\" found that the CAVIN4 protein was overexpressed in various types of cancer, including brain tumors. The researchers suggested that targeting the CAVIN4 protein using small molecules or antibodies may be a potential new approach to treating these cancers.

Drug Targeting Strategies for CAVIN4

One approach to targeting the CAVIN4 protein is to use small molecules that can inhibit its activity. Researchers have identified several small molecules that have been shown to interact with the CAVIN4 protein and may be potential drug candidates. For example, a study published in the journal \"Cancer Research\" found that the small molecule TQ-1245 inhibited the growth of cancer cells in a culture dish, and the researchers suggested that this compound may be a potential CAVIN4 inhibitor.

Another approach to targeting the CAVIN4 protein is to use antibodies that recognize and target specific regions of the protein. Researchers have identified several antibodies that have been shown to recognize and bind to the CAVIN4 protein, and these antibodies may be potential candidates for targeting the protein in cancer cells. For example, a study published in the journal \"Labors in Cancer Research\" found that an antibody against the CAVIN4 protein was able to block the growth of cancer cells in a culture dish.

Biomarker Development

While CAVIN4 has been shown to be involved in the development and progression of various types of cancer, it is important to note that further research is needed to develop biomarkers and clinical trials for this protein. Currently, there are no CAVIN4-based biomarkers or clinical trials that have been approved for use in the treatment of cancer.

Conclusion

In conclusion, CAVIN4 is a gene that encodes a protein that plays a critical role in the development and progression of various types of cancer, including brain tumors. While further research is needed to develop biomarkers and clinical trials for this protein, targeting the CAVIN4 protein using small molecules or antibodies may be a promising new approach to treating cancer. Further research is needed to determine the full potential of the CAVIN4 protein as a drug target and biomarker for cancer.

Protein Name: Caveolae Associated Protein 4

Functions: Modulates the morphology of formed caveolae in cardiomyocytes, but is not required for caveolar formation. Facilitates the recruitment of MAPK1/3 to caveolae within cardiomyocytes and regulates alpha-1 adrenergic receptor-induced hypertrophic responses in cardiomyocytes through MAPK1/3 activation. Contributes to proper membrane localization and stabilization of caveolin-3 (CAV3) in cardiomyocytes (By similarity). Induces RHOA activation and activates NPPA transcription and myofibrillar organization through the Rho/ROCK signaling pathway (PubMed:18332105)

The "CAVIN4 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about CAVIN4 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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