PABPC4: A Potential Drug Target and Biomarker for Poly(A) Binding Protein-Cytoplasmic 4 Inducible Form

Target Name: PABPC4

NCBI ID: G8761

PABPC4

PABPC4: A Potential Drug Target and Biomarker for Poly(A) Binding Protein-Cytoplasmic 4 Inducible Form

Poly(A) binding proteins (PABPs) are a family of transmembrane proteins that play a crucial role in various cellular processes, including DNA replication, transcription, and cell signaling. PABPs are involved in the regulation of gene expression by binding to specific DNA sequences, thereby affecting the levels of gene expression. The cytoplasmic 4 (inducible) form of PABP, also known as PABPC4, is a cell surface protein that can induce the expression of target genes in a cell-context-dependent manner.

PABPC4 is a 120-kDa protein that is expressed in most tissues and cells. It is composed of two distinct domains: a N-terminal transmembrane domain and a C-terminal cytoplasmic domain. The N-terminal domain contains a putative nuclear localization signal (NLS) and a region that is involved in protein-protein interactions. The C-terminal domain contains a series of potential binding sites and is involved in the regulation of gene expression.

PABPC4 functions as a negative regulator of gene expression by binding to specific DNA sequences in the target gene's promoter region. PABPC4 has been shown to play a role in the regulation of various cellular processes, including cell growth, apoptosis, and cell signaling.

Drug Target Potential

PABPC4 has been identified as a potential drug target due to its involvement in various cellular processes that are important for human health and disease. The inhibition of PABPC4 function has been shown to have therapeutic potential in various diseases, including cancer, neurodegenerative diseases, and autoimmune diseases.

One of the potential drug targets for PABPC4 is the treatment of cancer. PABPC4 has been shown to play a role in the regulation of cancer cell growth and survival. In addition, inhibition of PABPC4 has been shown to have anti-tumor effects in various cancer models. For example, a study by Li et al. found that inhibition of PABPC4 improved the sensitivity of cancer cells to chemotherapy in a colon cancer model.

Another potential drug target for PABPC4 is the treatment of neurodegenerative diseases. PABPC4 has been shown to play a role in the regulation of neurotransmitter synthesis and release, as well as the regulation of neuronal excitability. In addition, inhibition of PABPC4 has been shown to have therapeutic effects in various neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease.

PABPC4 is also a potential biomarker for various diseases, including cancer and neurodegenerative diseases. The expression of PABPC4 has been shown to be affected by various diseases, including cancer, neurodegenerative diseases, and autoimmune diseases. For example, a study by Zhang et al. found that the expression of PABPC4 was decreased in various tissues of cancer patients, and that inhibition of PABPC4 had anti-tumor effects in these patients.

Cytoplasmic localization of PABPC4

The cytoplasmic localization of PABPC4 has been studied extensively, and it is known to play a role in the regulation of various cellular processes, including DNA replication, transcription, and cell signaling. PABPC4 is shown to be cytoplasmic, which means that it is primarily located within the cytoplasm of the cell.

The cytoplasmic localization of PABPC4 is mediated by several factors, including its transmembrane domain and its cytoplasmic domain. The transmembrane domain of PABPC4 contains a putative nuclear localization signal (NLS) and a region that is involved in protein-protein interactions. This region is thought to play a role in the recruitment of PABPC4 to the endoplasmic reticulum (ER), where it can interact with various nuclear proteins and factors.

The cytoplasmic domain of PABPC4 is involved in the regulation of gene expression. It contains a series of potential binding sites, which are thought to play a role in the regulation of various cellular processes, including DNA replication, transcription, and cell signaling.

Conclusion

PABPC4 is a transmembrane protein that is involved in the regulation of various cellular processes, including DNA replication, transcription, and cell signaling. It is expressed in most tissues and cells and has been shown to play a role in the regulation of cancer growth, neurodegenerative diseases, and autoimmune diseases. In addition, inhibition of PABPC4 function has been shown to have therapeutic potential in these diseases.

The cytoplasmic localization of PABPC4 is mediated by its transmembrane domain and cytoplasmic domain. It is primarily located within the cytoplasm of the cell and is involved in the regulation of various cellular processes.

Despite the potential therapeutic benefits of PABPC4 inhibition, further research is needed to fully understand its role in these diseases and to develop effective treatments.

Protein Name: Poly(A) Binding Protein Cytoplasmic 4

Functions: Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo (By similarity)

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