PADI4: Potential Drug Target for Angiogenesis, Inflammation and Cell Survival

Target Name: PADI4

NCBI ID: G23569

PADI4

PADI4: Potential Drug Target for Angiogenesis, Inflammation and Cell Survival

Protein-arginine deiminase type IV (PADI4) is a protein that is expressed in various tissues throughout the body, including the brain, heart, kidneys, and intestines. It is involved in the breakdown of arginine, a amino acid that is important for the formation of blood vessels and the regulation of inflammation.

PADI4 has been identified as a potential drug target due to its role in the regulation of blood vessel formation and its potential to intervene in a variety of diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

One of the key functions of PADI4 is its role in the regulation of angiogenesis, the process by which new blood vessels are formed. PADI4 is involved in the breakdown of arginine, which is a key precursor for the formation of new blood vessels. By breaking down arginine, PADI4 helps to reduce the amount of available arginine in the blood, which in turn limits the ability of new blood vessels to form.

In addition to its role in blood vessel formation, PADI4 is also involved in the regulation of inflammation. Arginine has been shown to play a role in the regulation of immune responses and the production of pro-inflammatory cytokines. PADI4 has been shown to interact with immune cells and to regulate the production of pro-inflammatory cytokines.

PADI4 has also been shown to be involved in the regulation of cell survival. Arginine has been shown to play a role in the regulation of cell survival by maintaining the levels of cellular arginine. By maintaining the levels of arginine, PADI4 helps to ensure that cells are able to survive in the face of various stressors, including those that are caused by environmental toxins or diseases.

PADI4 is also involved in the regulation of cell signaling. Arginine has been shown to play a role in the regulation of cell signaling by participating in a variety of signaling pathways. PADI4 has been shown to interact with a variety of signaling molecules, including TGF-β and NF-kappa-B.

In conclusion, PADI4 is a protein that is involved in a variety of processes throughout the body. Its role in the regulation of blood vessel formation, inflammation, and cell survival and signaling makes it a potential drug target. Further research is needed to fully understand the role of PADI4 in these processes and to develop effective treatments for various diseases.

Protein Name: Peptidyl Arginine Deiminase 4

Functions: Catalyzes the citrullination/deimination of arginine residues of proteins such as histones, thereby playing a key role in histone code and regulation of stem cell maintenance (PubMed:15339660, PubMed:15345777, PubMed:16567635, PubMed:21245532). Citrullinates histone H1 at 'Arg-54' (to form H1R54ci), histone H3 at 'Arg-2', 'Arg-8', 'Arg-17' and/or 'Arg-26' (to form H3R2ci, H3R8ci, H3R17ci, H3R26ci, respectively) and histone H4 at 'Arg-3' (to form H4R3ci) (PubMed:15339660, PubMed:15345777, PubMed:16567635, PubMed:21245532). Acts as a key regulator of stem cell maintenance by mediating citrullination of histone H1: citrullination of 'Arg-54' of histone H1 (H1R54ci) results in H1 displacement from chromatin and global chromatin decondensation, thereby promoting pluripotency and stem cell maintenance (PubMed:15339660, PubMed:15345777, PubMed:16567635, PubMed:21245532). Promotes profound chromatin decondensation during the innate immune response to infection in neutrophils by mediating formation of H1R54ci (PubMed:18209087). Required for the formation of neutrophil extracellular traps (NETs); NETs are mainly composed of DNA fibers and are released by neutrophils to bind pathogens during inflammation (By similarity). Citrullination of histone H3 prevents their methylation by CARM1 and HRMT1L2/PRMT1 and represses transcription (PubMed:15345777). Citrullinates EP300/P300 at 'Arg-2142', which favors its interaction with NCOA2/GRIP1 (PubMed:15731352)

The "PADI4 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about PADI4 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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