Overview of PAICSP4: Potential Drug Target and Complex Role in Cellular Processes

Target Name: PAICSP4

NCBI ID: G780813

PAICSP4

Other Name(s): phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase pseudogene 4 | Phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase pseudogene 4

Overview of PAICSP4: Potential Drug Target and Complex Role in Cellular Processes

Phosphoribosylaminoimidazole carboxylase (PAICSP4) is a protein that is involved in the metabolism of nucleotides, which are the building blocks of DNA and RNA. Mutations in the PAICSP4 gene have been linked to a range of diseases, including cardiovascular diseases, neurodegenerative diseases, and cancer. In addition, over-expression of PAICSP4 has been shown to be associated with various diseases, including neuroinflammation and chronic pain.

Despite the growing interest in PAICSP4 and its potential as a drug target, much is still not known about this protein. In this article, we will provide an overview of PAICSP4, including its structure, function, and potential as a drug target.

Structure

PAICSP4 is a single-chain protein that contains 119 amino acids. It has a molecular weight of 18.5 kDa and a calculated pI of 6.5. PAICSP4 is localized to the endoplasmic reticulum (ER) and is predominantly expressed in the brain, heart, and kidneys. It is also expressed in the liver, pancreas, and gastrointestinal tract.

Function

PAICSP4 is involved in the metabolism of nucleotides, which are the building blocks of DNA and RNA. It catalyzes the conversion ofribosyl-AMINOIMIDAZOLE carboxylic acid toribosyl-AMINOIMIDAZOLE succinocarboxamide. This reaction is critical for the synthesis of nucleotides, which are then used to build up the DNA and RNA molecules that make up the cell.

In addition to its role in nucleotide synthesis, PAICSP4 is also involved in the regulation of cellular processes. It has been shown to play a role in the regulation of cell growth, differentiation, and inflammation.

Mutations in the PAICSP4 gene have been linked to a range of diseases, including cardiovascular diseases, neurodegenerative diseases, and cancer. For example, mutations in the PAICSP4 gene have been shown to contribute to the development of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. In addition, over-expression of PAICSP4 has been associated with various diseases, including neuroinflammation and chronic pain.

Despite the growing interest in PAICSP4 and its potential as a drug target, much is still not known about this protein. In addition, the precise mechanism of PAICSP4's involvement in these diseases is not yet fully understood. Further research is needed to fully elucidate the role of PAICSP4 in these processes and to develop effective treatments for its associated diseases.

Potential as a Drug Target

The potential of PAICSP4 as a drug target is based on its involvement in various diseases and its ability to regulate cellular processes.

One potential mechanism by which PAICSP4 could be targeted as a drug is its role in the regulation of cell growth and differentiation. PAICSP4 has been shown to play a negative role in cell proliferation, which could make it an attractive target for drugs that aim to inhibit cell growth.

Another potential mechanism by which PAICSP4 could be targeted as a drug is its role in the regulation of neurodegenerative diseases. Mutations in the PAICSP4 gene have been shown to contribute to the development of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. Therefore, drugs that are able to modify the activity of PAICSP4 could be an effective treatment for these diseases.

In addition, PAICSP4 has also been shown to be involved in the regulation of inflammation and pain. Over-expression of PAICSP4 has

Protein Name: Phosphoribosylaminoimidazole Carboxylase, Phosphoribosylaminoimidazole Succinocarboxamide Synthetase Pseudogene 4

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•   expression level;
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