Potential Drug Targets and Biomarkers for PAGE3 (G139793)

Target Name: PAGE3

NCBI ID: G139793

PAGE3

Potential Drug Targets and Biomarkers for PAGE3

PAGE3 (Proteasome-Accessible GTPase-3) is a protein that is expressed in various tissues and cells throughout the body. It is a key regulator of protein degradation and has been implicated in a wide range of cellular processes, including cell signaling, inflammation, and stress responses. Despite its importance, little is known about PAGE3 and its potential drug targets or biomarkers.

Drugs that target PAGE3 have the potential to treat a wide range of diseases, including neurodegenerative disorders, cancer, and cardiovascular disease. In this article, we will explore the biology of PAGE3 and its potential drug targets, as well as the current state of research in this field.

PAGE3 biology and function

PAGE3 is a member of the PAGE family of proteins, which are involved in the regulation of protein degradation. These proteins act as a scaffold to recruit and activate a variety of enzymes involved in protein degradation. PAGE3 is composed of 218 amino acid residues and has a calculated molecular mass of 33.1 kDa.

PAGE3 is expressed in a variety of tissues and cells, including the brain, muscle, heart, and intestine. It is highly expressed in the brain, with lower levels found in the muscle and heart. PAGE3 is also expressed in various cell types, including macrophages, dendritic cells, and epithelial cells.

PAGE3 plays a key role in regulating protein degradation, which is the process by which cells remove damaged or unnecessary proteins from their cells. This process is important for maintaining cellular homeostasis, as it allows cells to adapt to changing conditions and to remove toxins that may harm the cell.

PAGE3 is involved in a wide range of cellular processes that are important for normal cellular function. It is involved in the regulation of cell signaling, as it can interact with various signaling molecules, including TGF-β1, NF-kappa-B, and MAPK. PAGE3 is also involved in the regulation of inflammation, as it has been shown to play a role in the development of cancer.

PAGE3 is also involved in stress responses, as it has been shown to be regulated by stress-induced changes in the cellular environment. This suggests that PAGE3 may be a useful biomarker for stress-induced diseases, such as cancer and cardiovascular disease.

PAGE3 as a drug target

PAGE3 is a promising drug target due to its involvement in a wide range of cellular processes that are important for normal cellular function. Its ability to regulate protein degradation, as well as its involvement in various cellular processes, makes it an attractive target for drugs that are designed to promote protein synthesis or inhibit protein degradation.

One class of drugs that have been shown to target PAGE3 is the protein kinase inhibitors. These drugs work by inhibiting the activity of protein kinases, which are enzymes that regulate protein degradation. By inhibiting protein kinases, these drugs can promote protein synthesis and inhibit protein degradation, which can lead to increased protein levels and potentially harmful changes in cellular function.

Another class of drugs that have been shown to target PAGE3 is the small molecule inhibitors of PAGER-1 (Proteasome-Accessible GTPase-1-Regulated Enzyme 1). These drugs work by inhibiting the activity of PAGER-1, which is a protein that is involved in regulating protein degradation. By inhibiting PAGER-1, these drugs can promote protein synthesis and inhibit protein degradation, which can also lead to increased protein levels and potentially harmful changes in cellular function.

In addition to its potential as a drug target, PAGE3 is also a potential biomarker for a wide range of diseases. Its involvement in the regulation of protein degradation makes it an attractive target for drugs that are designed to promote protein synthesis or inhibit protein degradation in order to diagnose or

Protein Name: PAGE Family Member 3

The "PAGE3 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about PAGE3 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets