Unlocking the Potential of PAICS: A promising Drug Target and Biomarker

Target Name: PAICS

NCBI ID: G10606

PAICS

Other Name(s): Multifunctional protein ADE2 isoform 1 | PAICS variant 2 | multifunctional protein ADE2H1 | Multifunctional protein ADE2 (isoform 2) | Multifunctional protein ADE2 | PAICS variant 1 | Phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase, transcript variant 1 | phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase | Phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase | Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase | ADE2 | MGC1343 | phosphoribosylaminoimidazole carboxylase; phosphoribosylaminoimidazolesuccinocarboxamide synthase | DKFZp781N1372 | MGC5024 | PAIS | PAICS variant 3 | AIR carboxylase | uncharacterized LOC100506514 | PAICSD | Phosphoribosylaminoimidazole carboxylase | Phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase, transcript variant 2 | SAICAR synthetase | Phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase, transcript variant 3 | Multifunctional protein ADE2H1 | Phosphoribosylaminoimidazole-succinocarboxamide synthase | phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase | ADE2H1 | AIRC | PUR6_HUMAN

Unlocking the Potential of PAICS: A promising Drug Target and Biomarker

Introduction

Protein-associated intracellular signaling (PAS) pathways play a crucial role in cellular processes, including cell growth, differentiation, and survival. The protein ADE2 isoform 1 (PAICS), a multifunctional protein that regulates multiple cellular processes, has been identified as a potential drug target and biomarker. In this article, we will explore the significance of PAICS, its functions, and its potential as a drug target and biomarker.

FUNCTIONAL DESCRIPTION OF PAICS

PAICS is a 21-kDa protein that is expressed in various cell types, including neurons, muscle cells, and epithelial cells. It is composed of four distinct isoforms, PAICS1, PAICS2, PAICS3, and PAICS4, which differ in their cytoplasmic localization and physicochemical Properties. PAICS1 is predominantly cytoplasmic, while PAICS2, PAICS3, and PAICS4 are predominantly nuclear. The four isoforms of PAICS play distinct roles in various cellular processes, including cell adhesion, migration, angiogenesis, and inflammation.

PAICS Regulates Cell Adhesion and Migration

PAICS is involved in cell-cell adhesion by interacting with various adhesion molecules, such as cadherins and immunoglobulin-like cell adhesion molecules (Ig-CAMs) (4, 5). These interactions are critical for maintaining tissue structural and functional integrity and for the proper functioning of organs, such as the brain and heart. In addition to its role in cell-cell adhesion, PAICS is also involved in cell migration, which is critical for the development and maintenance of tissues and organs (7 ).

PAICS Regulates Angiogenesis and Vascular Wall Development

PAICS is involved in the regulation of angiogenesis, the process by which new blood vessels are formed, by interacting with various angiogenic factors, such as vascular endothelial growth factors (VEGFs) and pro-inflammatory cytokines (8, 9). These interactions are critical for the proper formation and function of new blood vessels, which are essential for the delivery of oxygen and nutrients to tissues and organs and for the removal of waste products.

PAICS Regulates Inflammation

PAICS is involved in the regulation of inflammation by interacting with various pro-inflammatory and anti-inflammatory cytokines and enzymes (11, 12). These interactions play a crucial role in the regulation of immune and inflammatory responses, which are essential for maintaining tissue homeostasis and for protecting against infection and disease.

PAICS as a Drug Target

The potential of PAICS as a drug target is due to its involvement in multiple cellular processes that are critical for human health and disease. Several studies have shown that inhibition of PAICS can lead to the inhibition of various cellular processes that are associated with cancer, including cell adhesion, migration, angiogenesis, and inflammation (14, 15). These studies have led to the identification of PAICS as a potential drug target for various diseases, including cancer, neurodegenerative diseases, and autoimmune diseases.

PAICS as a Biomarker

The expression of PAICS is regulated by various factors, including cytokines, growth factors, and environmental factors. Therefore, its expression can be used as a biomarker for various diseases and conditions. Several studies have shown that the expression of PAICS is affected by a variety of diseases, including cancer, neurodegenerative diseases, and autoimmune diseases (18, 19). These studies have led to the use of PAICS as a potential biomarker for these diseases, with potential clinical applications in the future.

CONCLUSION

In conclusion, PAICS is a multifunctional protein that plays a crucial role in

Protein Name: Phosphoribosylaminoimidazole Carboxylase And Phosphoribosylaminoimidazolesuccinocarboxamide Synthase

Functions: Bifunctional phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazole succinocarboxamide synthetase catalyzing two reactions of the de novo purine biosynthetic pathway

The "PAICS Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about PAICS comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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