Unlocking the Potential of PABPC3: A Promising Drug Target and Biomarker

Target Name: PABPC3

NCBI ID: G5042

PABPC3

Unlocking the Potential of PABPC3: A Promising Drug Target and Biomarker

Introduction

Poly(A)-binding protein 3 (PABPC3) is a protein that plays a crucial role in various cellular processes, including DNA replication, transcription, and apoptosis. It is a key regulator of the cell's interplay with the environment and its internal stress response . PABPC3 has also been implicated in various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. As a result, targeting PABPC3 has the potential to offer new therapeutic approaches for these diseases.

PABPC3: Structure and Function

PABPC3 is a 22kDa protein that is composed of 126 amino acid residues. It has a unique structure that consists of a 15kDa 伪-helix, a 2kDa 尾-sheet, and an 11kDa 纬-helix. It localizes intracellularly in the nucleolus and can enter the cytoplasm through nuclear pores. The main function of PABPC3 is to bind DNA and play a role in DNA replication, transcription and cell cycle regulation.

Under normal conditions, PABPC3 regulates DNA binding through phosphorylation modification. Phosphorylation can cause the 伪-helix of PABPC3 to flatten, allowing DNA to bind more tightly. In addition, phosphorylation can also affect the stability of PABPC3, allowing it to maintain stable expression levels at different stages of the cell cycle.

The relationship between PABPC3 and diseases

Abnormal expression of PABPC3 is closely related to the occurrence and development of various diseases. Studies have found that overexpression of PABPC3 is associated with progression and treatment resistance in many cancers. For example, the expression level of PABPC3 is positively correlated with the invasive ability of breast, lung and colon cancers. In addition, PABPC3 is also closely related to the development of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease.

The relationship between PABPC3 and drugs

PABPC3 is a potential drug target. Researchers have found that many anti-tumor drugs, including antiretroviral drugs, anti-inflammatory drugs and neuroprotective drugs, can inhibit the function of PABPC3. These drugs inhibit the role of PABPC3 in tumor cells by interfering with the binding of PABPC3 to DNA and inhibiting phosphorylation modification.

Biomarkers for PABPC3

PABPC3 is a good biomarker that can be used to detect the efficacy of various diseases and drugs. For example, the expression level of PABPC3 can be used to detect the progression and treatment effect of cancers such as breast, lung and colon cancer. In addition, PABPC3 expression levels can also be used to detect the development and severity of neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease.

Therapeutic prospects of PABPC3

PABPC3 is a potential drug target that can be used to treat a variety of diseases. By inhibiting the function of PABPC3, the progression and therapeutic effects of tumor cells, neurodegenerative diseases, and other diseases can be inhibited. Future research can focus on developing drugs for PABPC3, with a view to providing new ways to treat these diseases.

in conclusion

PABPC3 is a very important protein that plays an important role in cell life activities. Abnormal expression of PABPC3 is closely related to the occurrence and development of various diseases. PABPC3 is also associated with drug targets and is a potential drug target. Therefore, future research can focus on developing drugs for PABPC3 in order to provide new methods for the treatment of these diseases.

Protein Name: Poly(A) Binding Protein Cytoplasmic 3

Functions: Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism. Binds poly(A) with a slightly lower affinity as compared to PABPC1

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•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
•   disease relevance;
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•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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