Pallidin: A Protein Target for Small Molecules (G23022)

Target Name: PALLD

NCBI ID: G23022

PALLD

Pallidin: A Protein Target for Small Molecules

Pallidin (FLJ38193) is a protein that is expressed in various tissues of the body, including the brain. It is a member of the family of phosphatidylinositol (PI) transfer proteins, which are involved in the transfer of phosphate groups from various sources to different targets in the cell. PALLD is of particular interest as a potential drug target or biomarker, due to its known functions in various cellular processes and its expression in certain diseases.

PALLD function

PALLD is involved in the regulation of various cellular processes, including cell signaling, intracellular signaling, and the regulation of protein stability. It plays a critical role in the intracellular signaling pathway known as the TOR (T-cell oncogene-related) pathway. This pathway is involved in the regulation of cell growth, apoptosis, and sensitivity to various stimuli, including treatments that are designed to inhibit it.

One of the well-documented functions of PALLD is its role in the regulation of protein stability. PALLD has been shown to interact with various protein substrates, including the protein p70NTR, which is involved in the regulation of protein stability. This interaction between PALLD and p70NTR has been shown to play a role in the regulation of cellular processes such as cell signaling and protein translation.

Another function of PALLD is its role in cell signaling. PALLD has been shown to be involved in the regulation of various signaling pathways, including the PI signaling pathway, the TOR pathway, and the NF-kappa-B pathway. It has been shown to play a role in the regulation of cellular processes such as cell growth, apoptosis, and sensitivity to various stimuli.

PALLD and disease

PALLD is involved in the regulation of various cellular processes that are implicated in various diseases. For example, PALLD has been shown to be involved in the regulation of cell apoptosis, which is the process by which cells undergo programmed cell death. It has been shown to play a role in the regulation of apoptosis, by interacting with various proteins involved in this process, including Bcl-2.

PALLD has also been shown to be involved in the regulation of cell growth and sensitivity to various stimuli. For example, it has been shown to play a role in the regulation of cell proliferation, by interacting with the protein PDGF-R2. It has also been shown to play a role in the regulation of cellular sensitivity to various stimuli, such as UV radiation and chemical stress.

PALLD as a drug target

PALLD is a potential drug target, due to its involvement in various cellular processes that are implicated in various diseases. Its functions in cell signaling, protein stability, and cell apoptosis make it an attractive target for small molecules that can modulate its activity.

One approach to targeting PALLD is to use small molecules that modulate its activity in cell signaling pathways. For example, small molecules that inhibit the activity of PALLD's downstream effectors, such as the protein p70NTR, could be used to reduce the activity of PALLD and its downstream targets. Similarly, small molecules that modulate PALLD's activity in cell apoptosis pathways, such as the inhibitor of apoptosis (IAP) protein, could also be used to target PALLD and its activity in this pathway.

Another approach to targeting PALLD is to use small molecules that modulate its activity in cell signaling pathways and in the regulation of protein stability. For example, small molecules that modulate the activity of PALLD's downstream effectors, such as the protein

Protein Name: Palladin, Cytoskeletal Associated Protein

Functions: Cytoskeletal protein required for organization of normal actin cytoskeleton. Roles in establishing cell morphology, motility, cell adhesion and cell-extracellular matrix interactions in a variety of cell types. May function as a scaffolding molecule with the potential to influence both actin polymerization and the assembly of existing actin filaments into higher-order arrays. Binds to proteins that bind to either monomeric or filamentous actin. Localizes at sites where active actin remodeling takes place, such as lamellipodia and membrane ruffles. Different isoforms may have functional differences. Involved in the control of morphological and cytoskeletal changes associated with dendritic cell maturation. Involved in targeting ACTN to specific subcellular foci

The "PALLD Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about PALLD comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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