SLC5A1: A Potential Drug Target for Neurological Disorders (G6523)

Target Name: SLC5A1

NCBI ID: G6523

SLC5A1

SLC5A1: A Potential Drug Target for Neurological Disorders

SLC5A1 (NAGT), or solute carrier family 5 member 1, is a protein that is expressed in various tissues throughout the body. It is a transmembrane protein that is involved in the transport of a variety of molecules, including nutrients, drugs, and waste products. SLC5A1 is also known as NAGT, or neurotrophic factor-related G protein-coupled receptor, and it is a potential drug target and biomarker.

SLC5A1 is expressed in the brain and is involved in the delivery of neurotransmitters, such as dopamine, serotonin, and endothelial factors, to different target cells. It is also involved in the clearance of harmful substances, such as neurotoxins, and in modulating pain perception. SLC5A1 has been shown to be involved in a variety of neurological and psychiatric disorders, including Alzheimer's disease, Parkinson's disease, and depression.

In addition to its role in neurotransmission, SLC5A1 is also involved in the regulation of inflammation and immune responses. It has been shown to play a role in the regulation of pain sensitivity and the modulation of inflammatory responses. SLC5A1 has also been shown to be involved in the regulation of cell survival and proliferation, and it is a potential target for drugs that aim to promote neurogenesis and repair.

SLC5A1 is also a potential biomarker for a variety of neurological and psychiatric disorders. Its expression has been shown to be altered in a variety of neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and Huntington's disease. It has also been shown to be involved in the regulation of mood and anxiety, and it may be a potential target for drugs that aim to treat these conditions.

SLC5A1 is also a potential drug target for other diseases and conditions. Its involvement in the regulation of neurotransmission and immune responses makes it a potential target for drugs that aim to treat a variety of neurological and psychiatric disorders, including anxiety, depression, and pain. It is also a potential target for drugs that aim to promote neurogenesis and repair, and it may be a useful tool for the development of new therapies for neurodegenerative diseases.

In conclusion, SLC5A1 is a transmembrane protein that is involved in the transport of a variety of molecules throughout the body. It is a potential drug target and biomarker for a variety of neurological and psychiatric disorders, including Alzheimer's disease, Parkinson's disease, and depression. Its involvement in the regulation of neurotransmission, inflammation, and immune responses also makes it a potential target for drugs that aim to treat a variety of conditions. Further research is needed to fully understand the role of SLC5A1 in these processes and to develop new treatments for neurodegenerative diseases.

Protein Name: Solute Carrier Family 5 Member 1

Functions: Electrogenic Na(+)-coupled sugar simporter that actively transports D-glucose or D-galactose at the plasma membrane, with a Na(+) to sugar coupling ratio of 2:1. Transporter activity is driven by a transmembrane Na(+) electrochemical gradient set by the Na(+)/K(+) pump (PubMed:20980548, PubMed:35077764, PubMed:8563765, PubMed:34880492). Has a primary role in the transport of dietary monosaccharides from enterocytes to blood. Responsible for the absorption of D-glucose or D-galactose across the apical brush-border membrane of enterocytes, whereas basolateral exit is provided by GLUT2. Additionally, functions as a D-glucose sensor in enteroendocrine cells, triggering the secretion of the incretins GCG and GIP that control food intake and energy homeostasis (PubMed:8563765) (By similarity). Together with SGLT2, functions in reabsorption of D-glucose from glomerular filtrate, playing a nonredundant role in the S3 segment of the proximal tubules (By similarity). Transports D-glucose into endometrial epithelial cells, controlling glycogen synthesis and nutritional support for the embryo as well as the decidual transformation of endometrium prior to conception (PubMed:28974690). Acts as a water channel enabling passive water transport across the plasma membrane in response to the osmotic gradient created upon sugar and Na(+) uptake. Has high water conductivity, comparable to aquaporins, and therefore is expected to play an important role in transepithelial water permeability, especially in the small intestine

The "SLC5A1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about SLC5A1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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