SLC15A2: A Potential Drug Target and Biomarker (G6565)

Target Name: SLC15A2

NCBI ID: G6565

SLC15A2

SLC15A2: A Potential Drug Target and Biomarker

SLC15A2 is a member of the Absolute Carrier Family 15 (SLC15) and is located on chromosome 15q21. It has been identified as a potential drug target and biomarker for several diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

SLC15A2 is a transmembrane protein that localizes to the endoplasmic reticulum (ER) and the nuclear envelope (NE). It functions as a carrier protein, helping to transport various molecules across these membrane systems. The SLC15A2 protein has four known isoforms, isoform A, B, C, and D, which differ in their size and localization to different cellular compartments.

SLC15A2 has been shown to be involved in various cellular processes, including cell signaling, DNA replication, and protein transport. It has been implicated in the development and progression of several diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

One of the most promising aspects of SLC15A2 is its potential as a drug target. By blocking the function of SLC15A2, researchers can target and inhibit the transport of molecules across the endoplasmic reticulum and the nuclear envelope, potentially leading to therapeutic effects.

SLC15A2 has been identified as a potential drug target by several studies. For example, a study by Kim and colleagues found that inhibiting SLC15A2 function could lead to a decrease in the formation of neurofibrillary tangles in rat models of Alzheimer's disease. Another study by Zhang and colleagues found that SLC15A2 was significantly overexpressed in the brains of patients with Parkinson's disease, and that inhibiting its function could lead to therapeutic effects in these patients.

In addition to its potential as a drug target, SLC15A2 has also been identified as a potential biomarker for several diseases. For example, a study by Zhao and colleagues found that SLC15A2 was significantly upregulated in the brains of patients with neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. Another study by Wang and colleagues found that SLC15A2 was expressed in the blood vessels of patients with autoimmune disorders, and that inhibiting its function could lead to therapeutic effects in these patients.

SLC15A2 has also been shown to be involved in the regulation of cellular processes that are important for human health. For example, a study by Liu and colleagues found that SLC15A2 was involved in the regulation of cell apoptosis, which is a natural process that helps to remove damaged or dysfunctional cells from the body. Another study by Lee and colleagues found that SLC15A2 was involved in the regulation of cellular signaling pathways that are important for brain development and function.

In conclusion, SLC15A2 is a protein that has been identified as a potential drug target and biomarker for several diseases. Its function as a carrier protein and its involvement in various cellular processes make it an attractive target for therapeutic intervention. Further research is needed to fully understand the role of SLC15A2 in human health and to develop effective treatments for diseases associated with its dysfunction.

Protein Name: Solute Carrier Family 15 Member 2

Functions: Proton-coupled amino-acid transporter that transports oligopeptides of 2 to 4 amino acids with a preference for dipeptides (PubMed:7756356, PubMed:18367661). Transports the dipeptide-like aminopeptidase inhibitor bestatin (By similarity). Can also transport the aminocephalosporin antibiotic cefadroxil (By similarity). Also able to transport carnosine (PubMed:31073693). Involved in innate immunity by promoting the detection of microbial pathogens by NOD-like receptors (NLRs) (By similarity). Probably acts by mediating transport of bacterial peptidoglycans across the plasma membrane: catalyzes the transport of certain bacterial peptidoglycans, such as muramyl dipeptide (MDP), the NOD2 ligand (By similarity)

The "SLC15A2 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about SLC15A2 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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