SLC17A5: A Potential Drug Target and Biomarker (G26503)

Target Name: SLC17A5

NCBI ID: G26503

SLC17A5

SLC17A5: A Potential Drug Target and Biomarker

Solute carrier family 17 (ANION/SUGAR TRANSPORTER) member 5 (SLC17A5) is a protein that plays a crucial role in the transport of anions and sugars in various organisms, including humans. The ANION/SUGAR TRANSPORTER superfamily consists of different transporters that mediate the transport of a wide range of anions and sugars across cell membranes. SLC17A5, specifically, is a member of this family and is involved in the transport of anions, such as hypochloride ions (H+), as well as sugars, including glucose and sucrose.

SLC17A5 is a 21-kDa protein that is expressed in various tissues and organs, including the brain, heart, kidney, and liver. It is primarily localized to the endoplasmic reticulum (ER) and endosomal system (ES), which are specialized structures responsible for the delivery of proteins to the cell membrane and the retrieval of proteins from the cell membrane, respectively. SLC17A5 functions as a transporter of anions and sugars across the cell membrane and is critical for maintaining the homeostasis of various physiological processes in the cell.

SLC17A5 has been identified as a potential drug target due to its involvement in various diseases, including diabetes, heart disease, and neurodegenerative disorders. The ANION/SUGAR TRANSPORTER superfamily has been implicated in the development and progression of various diseases, including diabetes, where ANION /SUGAR TRANSPORTER family member 5 has been shown to be involved in the regulation of insulin sensitivity and glucose metabolism.

SLC17A5 has also been identified as a potential biomarker for various diseases, including diabetes and heart disease. The ANION/SUGAR TRANSPORTER superfamily is involved in the regulation of various physiological processes in the body, including glucose and insulin regulation, which are critical for maintaining the health and function of the body. Therefore, changes in the expression and function of SLC17A5 may be indicative of underlying diseases, including diabetes and heart disease.

SLC17A5 has also been shown to be involved in the regulation of neurotransmitter synthesis and release, which are critical for the function of the nervous system. The ANION/SUGAR TRANSPORTER superfamily has been implicated in the regulation of various neurotransmitters, including dopamine, serotonin, and kappa-opioid antagonist (KOAT) neurotransmitters, which are involved in mood regulation, pain perception, and neurotransmission, respectively. Therefore, changes in the expression and function of SLC17A5 may be indicative of neurodegenerative disorders, including Alzheimer's disease and Parkinson's disease.

In conclusion, SLC17A5 is a potential drug target and biomarker that has been identified for its involvement in various diseases, including diabetes, heart disease, and neurodegenerative disorders. Further research is needed to fully understand the role of SLC17A5 in these diseases and to develop effective therapies that target this protein.

Protein Name: Solute Carrier Family 17 Member 5

Functions: Multifunctional anion transporter that operates via two distinct transport mechanisms, namely proton-coupled anion cotransport and membrane potential-dependent anion transport (PubMed:15510212, PubMed:21781115, PubMed:22778404, PubMed:23889254). Electroneutral proton-coupled acidic monosaccharide symporter, with a sugar to proton stoichiometry of 1:1. Exports glucuronic acid and free sialic acid derived from sialoglycoconjugate degradation out of lysosomes, driven by outwardly directed lysosomal pH gradient. May regulate lysosome function and metabolism of sialylated conjugates that impact oligodendrocyte lineage differentiation and myelinogenesis in the central nervous system (PubMed:15510212, PubMed:21781115, PubMed:22778404, PubMed:23889254) (By similarity). Electrogenic proton-coupled nitrate symporter that transports nitrate ions across the basolateral membrane of salivary gland acinar cells, with nitrate to proton stoichiometry of 2:1. May contribute to nitrate clearance from serum by salivary glands, where it is further concentrated and secreted in the saliva (PubMed:22778404). Uses membrane potential to drive the uptake of acidic amino acids and peptides into synaptic vesicles. Responsible for synaptic vesicular storage of L-aspartate and L-glutamate in pinealocytes as well as vesicular uptake of N-acetyl-L-aspartyl-L-glutamate neuropeptide, relevant to aspartegic-associated glutamatergic neurotransmission and activation of metabotropic receptors that inhibit subsequent transmitter release (PubMed:21781115, PubMed:22778404, PubMed:23889254) (By similarity)

The "SLC17A5 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about SLC17A5 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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