TRPM8: A Protein Involved in Pain, Inflammation and Neurotransmitter Signaling

Target Name: TRPM8

NCBI ID: G79054

TRPM8

TRPM8: A Protein Involved in Pain, Inflammation and Neurotransmitter Signaling

TRPM8 (Tyrosine-protein kinase subfamily G member 8) is a protein that is expressed in various tissues and cells throughout the body. It is known for its role in the regulation of pain, inflammation, and neurotransmitter signaling. TRPM8 has also been implicated in the development and progression of certain diseases, including cancer.

One of the key functions of TRPM8 is its role in pain signaling. When the body experiences pain, TRPM8 is activated and sends signals to the brain to communicate this information. This signaling cascade is crucial for the body's ability to respond to pain and protect itself from injury.

In addition to its role in pain signaling, TRPM8 is also involved in the regulation of inflammation. When the body experiences inflammation, TRPM8 is activated and helps to coordinate the immune response. This is important for fighting off infections and removing damaged tissue from the body.

TRPM8's role in neurotransmitter signaling is also of interest, as it has been implicated in the development and progression of certain neurological disorders. For example, TRPM8 has been shown to play a role in the development of Alzheimer's disease, and may also contribute to the development of other neurological conditions such as Parkinson's disease and multiple sclerosis.

Another potential drug target for TRPM8 is its role in cancer progression. Studies have shown that TRPM8 is often overexpressed in cancer cells, and that inhibiting its activity may be an effective way to treat cancer. This is because when TRPM8 is activated, it can promote the growth and survival of cancer cells. By inhibiting its activity, researchers may be able to slow down or even stop the progression of cancer.

In conclusion, TRPM8 is a protein that plays a crucial role in the regulation of pain, inflammation, and neurotransmitter signaling. It is also implicated in the development and progression of certain diseases, including cancer. As a drug target, TRPM8 may offer new treatments for a variety of conditions. Further research is needed to fully understand its role and potential as a drug.

Protein Name: Transient Receptor Potential Cation Channel Subfamily M Member 8

Functions: Receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. Activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH. Involved in menthol sensation. Permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium. Temperature sensing is tightly linked to voltage-dependent gating. Activated upon depolarization, changes in temperature resulting in graded shifts of its voltage-dependent activation curves. The chemical agonist menthol functions as a gating modifier, shifting activation curves towards physiological membrane potentials. Temperature sensitivity arises from a tenfold difference in the activation energies associated with voltage-dependent opening and closing. In prostate cancer cells, shows strong inward rectification and high calcium selectivity in contrast to its behavior in normal cells which is characterized by outward rectification and poor cationic selectivity. Plays a role in prostate cancer cell migration (PubMed:25559186). Isoform 2 and isoform 3 negatively regulate menthol- and cold-induced channel activity by stabilizing the closed state of the channel

The "TRPM8 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about TRPM8 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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