ZFAND1: Characteristics and Functions of An AN1-Type Zinc Finger Protein

Target Name: ZFAND1

NCBI ID: G79752

ZFAND1

ZFAND1: Characteristics and Functions of An AN1-Type Zinc Finger Protein

Zinc Finger AN1-Type-Containing Protein 1 (ZFAND1) is a protein that is expressed in various tissues and cells throughout the body. It is a member of the zinc finger gene family, which is a family of proteins that contain a zinc finger domain . The zinc finger domain is a structural motif that is characterized by the presence of a zinc atom that is coordination bonded to a specific amino acid residue. ZFAND1 is unique because it is a type of AN1-type zinc finger protein.

The AN1-type zinc finger protein is a subfamily of the zinc finger proteins, which are a family of non-coding RNAs that play important roles in various cellular processes. AN1-type zinc finger proteins are characterized by the presence of a specific zinc finger domain that is located at the base of the protein. This zinc finger domain is responsible for the protein's unique structure and function.

ZFAND1 is a 21-kDa protein that is expressed in various tissues and cells throughout the body. It is highly conserved, with a calculated amino acid sequence of 21.15% identity to the mouse protein NIP/YAP. ZFAND1 is primarily localized to the cytoplasm of the cell, and is also found in the endoplasmic reticulum and the nuclear envelope.

The zinc finger domain is a structural motif that is characterized by the presence of a zinc atom that is coordination bonded to a specific amino acid residue. This motif is found in many proteins, including ZFAND1. The zinc finger domain is responsible for the protein's unique structure and function.

One of the unique features of ZFAND1 is its expression pattern. It is primarily expressed in the cytoplasm of the cell, and is also found in the endoplasmic reticulum and the nuclear envelope. This suggests that it may play a role in the regulation of various cellular processes that are occurring in the cytoplasm.

In addition to its expression pattern, ZFAND1 also has unique functional characteristics. It is a type of AN1-type zinc finger protein, which is characterized by the presence of a specific zinc finger domain. This zinc finger domain is responsible for the protein's unique structure and function.

The zinc finger domain is a structural motif that is characterized by the presence of a zinc atom that is coordination bonded to a specific amino acid residue. This motif is found in many proteins, including ZFAND1. The zinc finger domain is responsible for the protein's unique structure and function.

One of the unique features of ZFAND1 is its expression pattern. It is primarily expressed in the cytoplasm of the cell, and is also found in the endoplasmic reticulum and the nuclear envelope. This suggests that it may play a role in the regulation of various cellular processes that are happening in the cytoplasm.

In addition to its expression pattern, ZFAND1 also has unique functional characteristics. It is a type of AN1-type zinc finger protein, which is characterized by the presence of a specific zinc finger domain. This zinc finger domain is responsible for the protein's unique structure and function.

The AN1-type zinc finger protein is a subfamily of the zinc finger proteins, which are a family of non-coding RNAs that play important roles in various cellular processes. ZFAND1 is a unique protein because it is a type of AN1-type zinc finger protein, and because it has specific structural characteristics that are characteristic of this subfamily of proteins.

ZFAND1 is a protein that is expressed in various tissues and cells throughout the body. It is highly conserved, with a calculated amino acid sequence of 21.15% identity to the mouse protein NIP/YAP. ZFAND1 is primarily localized to the cytoplasm of the cell, and is also found in the endoplasmic reticulum and the nuclear envelope. Its unique structure, including the presence of a zinc finger domain, is responsible for its unique function and the regulation of various cellular processes.

Protein Name: Zinc Finger AN1-type Containing 1

Functions: Plays a role in the regulation of cytoplasmic stress granules (SGs) turnover. SGs are dynamic and transient cytoplasmic ribonucleoprotein assemblies important for cellular protein homeostasis when protein production is suspended after acute exogenous stress (PubMed:29804830). Associates with SGs and is involved in the efficient and specific arsenite-induced clearance process of SGs through the recruitment of the ubiquitin-selective ATPase VCP and the 26S proteasome (PubMed:29804830). This process requires both complexes for efficient degradation of damaged ubiquitinated SG proteins during recovery from arsenite stress, and hence avoiding aberrant cytoplasmic SGs degradation via autophagy (PubMed:29804830)

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