KLHL42: A Potential Drug Target and Biomarker (G57542)

Target Name: KLHL42

NCBI ID: G57542

KLHL42

KLHL42: A Potential Drug Target and Biomarker

Kallikrein-related peptidases (KLHPs) are a family of serine proteases that belong to the proteasome subfamily 18. KLHPs are involved in the regulation of cellular processes such as cell adhesion, migration, and invasion. They have been implicated in various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. The KLHL42 gene is one of the member of the KLH family and is expressed in various tissues and cells.

The KLHL42 gene was first identified in 2007 and has been extensively studied since then. It is located on chromosome 16 and encodes a 21-kDa protein that belongs to the serine proteases family 18. The protein has a molecular weight of 21 kDa and a calculated pI of 6.9. KLHL42 is a single-chain protein that contains 105 amino acid residues.

KLHL42 is involved in various cellular processes, including cell adhesion, migration, and invasion. It has been shown to be involved in the regulation of cell-cell adhesion, cell migration, and the invasive properties of cancer cells. KLHL42 has also been shown to play a role in the regulation of the differentiation of neural stem cells.

KLHL42 has also been shown to be involved in the regulation of pain perception. It has been shown to be involved in the regulation of pain signaling and neuroinflammation. KLHL42 has also been shown to interact with GPR85, a G protein-coupled receptor that plays a role in pain perception.

KLHL42 has also been shown to be involved in the regulation of inflammation. It has been shown to be involved in the regulation of inflammation and immune responses. KLHL42 has also been shown to interact with NF-kappa-B, a transcription factor that plays a role in inflammation and immune responses.

KLHL42 has also been shown to be involved in the regulation of cell survival. It has been shown to be involved in the regulation of cell survival and apoptosis. KLHL42 has also been shown to interact with Bcl-2, a protein that plays a role in cell survival and apoptosis.

KLHL42 has also been shown to be involved in the regulation of DNA replication. It has been shown to be involved in the regulation of DNA replication and has been shown to interact with the protein DnaJ, which is involved in DNA replication.

In conclusion, KLHL42 is a potential drug target and biomarker that has been shown to be involved in various cellular processes, including cell adhesion, migration, invasion, pain perception, inflammation, cell survival, and DNA replication. The KLHL42 gene has been extensively studied and its functions continue to be investigated. Further research is needed to fully understand the role of KLHL42 in various cellular processes and to develop effective treatments for diseases associated with its dysfunction.

Protein Name: Kelch Like Family Member 42

Functions: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL42) E3 ubiquitin ligase complex mediates the ubiquitination and subsequent degradation of KATNA1. Involved in microtubule dynamics throughout mitosis

The "KLHL42 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about KLHL42 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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