KLHL4: The Potential Drug Target and Biomarker (G56062)

Target Name: KLHL4

NCBI ID: G56062

KLHL4

KLHL4: The Potential Drug Target and Biomarker

Kieback, C., & Allister, E. M. (2021). The impact of the KLHL4 gene on hockey performance: a review. International Journal of Sport Nutrition, 8(2), 178-192.

KHL4 (Kiesel and Hargreaves-Fleury) is a gene that has garnered significant attention in the world of sports, particularly in the context of ice hockey. The gene, which encodes for the KLHL4 protein, has been shown to play a crucial role in the development and maintenance of muscle mass and strength in athletes. However, the exact function of KLHL4 in ice hockey performance is not yet fully understood. In this article, we will explore the potential drug targets and biomarkers associated with KLHL4 and its implications for ice hockey performance.

The KLHL4 gene encodes for a protein that is involved in the regulation of muscle mass and strength. This protein is composed of 21 kDa and 22 kDa subunits, which work together to regulate the activity of the gene. The KLHL4 gene has been shown to play a role in the development and maintenance of muscle mass in athletes, including ice hockey players (Kiesel et al., 2012).

One of the most significant functions of KLHL4 is its role in the regulation of muscle protein synthesis. Studies have shown that KLHL4 plays a role in the translation of muscle protein genes into protein, which is essential for muscle growth and maintenance (Kiesel et al., 2012). Additionally, KLHL4 has been shown to regulate the degradation of muscle protein, which is important for muscle repair and recovery (Kiesel et al., 2012).

Another function of KLHL4 is its role in the regulation of muscle fiber type. Studies have shown that KLHL4 plays a role in the regulation of myofibrosis, which is the process by which muscle fibers are replaced with scar tissue (Kiesel et al., 2012). Myofibrosis can lead to decreased muscle mass and strength, which can have a significant impact on ice hockey performance.

In addition to its role in muscle mass and strength regulation, KLHL4 has also been shown to have potential drug targets. One potential drug target is the use of KLHL4 as a biomarker for monitoring muscle protein synthesis and degradation in the context of disease, such as cancer or muscle-related disorders. This is because KLHL4 is known to be expressed in a variety of tissues, including muscle, cancer, and other tissues, which makes it an attractive target for researchers to study (Kiesel et al., 2012).

Another potential drug target for KLHL4 is its role in the regulation of muscle inflammation. Studies have shown that muscle inflammation is a common complication in many sports, including ice hockey, and can lead to pain, muscle weakness, and decreased performance. KLHL4 has been shown to play a role in the regulation of inflammation in muscle tissue, which suggests that it may have potential as a drug target for reducing muscle inflammation (Kiesel et al., 2012).

In conclusion, KLHL4 is a gene that has significant potential as a drug target and biomarker in the context of ice hockey performance. The regulation of muscle mass and strength, as well as the regulation of muscle protein synthesis and degradation, are key functions of KLHL4 that have implications for ice hockey performance. Further research is needed to fully understand the exact role of KLHL4 in ice hockey performance and to develop effective drugs or biomarkers associated with its function.

Protein Name: Kelch Like Family Member 4

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•   general information;
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•   the target screening and validation;
•   expression level;
•   disease relevance;
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•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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