PDRG1 Regulates P53 and DNA Damage Response (G81572)

Target Name: PDRG1

NCBI ID: G81572

PDRG1

PDRG1 Regulates P53 and DNA Damage Response

PDRG1 (p53 and DNA damage regulated gene 1) is a non-coding RNA molecule that plays a crucial role in cellular processes. It is a key regulator of the DNA damage response (DDR), which is a series of cellular pathways that respond to DNA damage and ensure the integrity of the genetic material. PDRG1 is a well-known protein that is expressed in various tissues and cells, including the brain, spinal cord, and peripheral tissues. It is composed of 214 amino acid residues and has a calculated molecular weight of 21.9 kDa.

PDRG1 functions as a negative regulator of the p53 protein, which is a well-known tumor suppressor gene that plays a crucial role in the DDR. The p53 protein is composed of 41 amino acid residues and has a calculated molecular weight of 4.3 kDa. It is a key regulator of the DNA damage response and is involved in the execution of various cellular processes, including DNA replication, repair, and apoptosis.

PDRG1 functions as a positive regulator of the p53 protein by promoting the accumulation of p53 in the cytoplasm and the nuclear envelope. This accumulation of p53 is important for the regulation of cellular processes, including the execution of the DDR. PDRG1 does this by binding to the p53 protein and promoting the formation of a protein-protein interaction between PDRG1 and p53. This interaction between PDRG1 and p53 is critical for the regulation of the DDR and is a key target for the development of new cancer therapies.

PDRG1 is also involved in the regulation of DNA damage repair, which is an important process for the maintenance of cellular homeostasis. DNA damage repair is a critical process that ensures the integrity of the genetic material and protects against the development of mutations. PDRG1 plays a crucial role in this process by regulating the activity of several DNA repair pathways, including the base excision repair (BER) pathway.

PDRG1 is also involved in the regulation of apoptosis, which is an important process for the elimination of damaged or dysfunctional cells. Apoptosis is a process that is regulated by a variety of factors, including the expression of p53. PDRG1 plays a crucial role in this process by regulating the activity of p53, which is involved in the execution of apoptosis.

PDRG1 is also involved in the regulation of cellular signaling pathways, including the TGF-β pathway. TGF-β is a critical pathway involved in the regulation of cellular growth, differentiation, and survival. PDRG1 plays a crucial role in this pathway by regulating the activity of several TGF-β signaling pathway components, including the transcription factor SMAD1.

PDRG1 is also involved in the regulation of gene expression, which is an important process that ensures the expression of specific genes in response to various cellular stimuli. PDRG1 plays a crucial role in this process by regulating the activity of several transcription factors, including RNA polymerase II (RNA-II).

PDRG1 is also involved in the regulation of protein translation, which is an important process that ensures the production of specific proteins in response to cellular stimuli. PDRG1 plays a crucial role in this process by regulating the activity of several translation factors, including the eIF4F complex.

PDRG1 is also involved in the regulation of cellular signaling pathways, including the PI3K/AKT signaling pathway. PI3K/AKT is a critical pathway involved in the regulation of cellular signaling pathways, including cell survival and angiogenesis. PDRG1 plays a crucial role in this pathway by regulating the activity of several PI3K/AKT signaling pathway components, including the protein kinase A1 (PKA1).

PDRG1 is also involved in the regulation of cellular signaling pathways, including the NF-kappa-B signaling pathway. NF-kappa-B is a critical pathway involved in the regulation of cellular signaling pathways, including inflammation and stress responses.

Protein Name: P53 And DNA Damage Regulated 1

Functions: May play a role in chaperone-mediated protein folding

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