PDXK: A Potential Drug Target and Biomarker (G8566)

Target Name: PDXK

NCBI ID: G8566

PDXK

PDXK: A Potential Drug Target and Biomarker

PDXK (Pyruvate Kinase) is a protein that is expressed in various tissues throughout the body, including the brain, muscle, and heart. It plays a crucial role in the metabolism of pyruvate, which is a critical intermediate step in the citric acid cycle, also known as the Krebs cycle or TCA cycle. Pyruvate is the final electron acceptor in the citric acid cycle, and PDXK is the enzyme that catalyzes the conversion of pyruvate to acetyl-CoA, which is then used to produce energy in the form of ATP.

PDXK is a member of the BENE family of proteins, which are characterized by the presence of a specific domain called the N-terminal hypervariable region (HVR). This region is involved in the formation of a unique alpha-helices and alpha-helical structures , as well as the formation of a disulfide bond.

PDXK has also been shown to play a role in various cellular processes, including metabolism, inflammation, and stress. It is involved in the regulation of cellular metabolism, particularly the citric acid cycle and the metabolism of fatty acids. a role in the regulation of inflammation and stress responses.

PDXK has also been shown to be a potential drug target. The high level of expression of PDXK in various tissues and the involvement in various cellular processes make it an attractive target for drug development. Additionally, the N-terminal HVR of PDXK makes it a potential target for small molecules that can modulate its activity.

In addition to its potential as a drug target, PDXK is also a potential biomarker. The metabolism of pyruvate is a critical step in the citric acid cycle, and the levels of pyruvate in various tissues can be affected by various factors, including diet, exercise , and stress. The levels of pyruvate in different tissues can be used as a marker for certain diseases, such as cancer, cardiovascular disease, and neurological disorders.

PDXK is also involved in the regulation of cellular stress responses. The stress response is a critical process that helps the body to cope with various environmental and biological stressors. PDXK plays a role in the regulation of cellular stress responses by participating in the stress-induced increase in the activity of the transcription factor, NF-kappa-B.

In conclusion, PDXK is a protein that plays a crucial role in various cellular processes, including metabolism, inflammation, and stress responses. Its high level of expression in various tissues and the involvement in various cellular processes make it an attractive target for drug development. Additionally, the N-terminal HVR of PDXK makes it a potential target for small molecules that can modulate its activity. Furthermore, the levels of pyruvate in different tissues can be used as a marker for certain diseases and PDXK is also involved in the regulation of cellular stress responses. Therefore, PDXK is a potential drug target and biomarker in various diseases.

Protein Name: Pyridoxal Kinase

Functions: Catalyzes the phosphorylation of the dietary vitamin B6 vitamers pyridoxal (PL), pyridoxine (PN) and pyridoxamine (PM) to form pyridoxal 5'-phosphate (PLP), pyridoxine 5'-phosphate (PNP) and pyridoxamine 5'-phosphate (PMP), respectively (PubMed:9099727, PubMed:10987144, PubMed:17766369, PubMed:19351586, PubMed:31187503) (Probable). PLP is the active form of vitamin B6, and acts as a cofactor for over 140 different enzymatic reactions

The "PDXK Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about PDXK comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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