PMFBP1: A Protein Target for Cancer Treatment (G83449)

Target Name: PMFBP1

NCBI ID: G83449

PMFBP1

PMFBP1: A Protein Target for Cancer Treatment

Peroxisome proliferator-activated receptor (PPAR) is a family of transcription factors, that regulates various cellular processes in the body, including inflammation, metabolism, and adhesion. PMFBP1 (PMFBP_HUMAN) is a protein coded by human gene PPAR未3. PMFBP1 is a key regulator of cellular processes that are crucial for the development, maintenance and function of various tissues in the body. Unfortunately, PMFBP1 has also been implicated in the development and progression of various diseases, including cancer. As a result, the study of PMFBP1 and its potential as a drug target is of great interest.

Expression and function:

PMFBP1 is a 14 kDa protein that is expressed in various tissues and cells in the body. It is highly homogeneous and has a calculated pI of 5.9. PMFBP1 is a nuclear protein that is predominantly localized to the nuclei of cells, and is also found in the cytoplasm. It is involved in the regulation of various cellular processes, including cell adhesion, migration, and the modulation of gene expression.

PMFBP1 plays a crucial role in the regulation of cell adhesion. It is a negative regulator of the cadherin gene, which encodes a transmembrane protein that is involved in cell-cell adhesion. PMFBP1 interacts with cadherin and inhibits its activity. This interaction between PMFBP1 and Cadherin is important for the regulation of cell adhesion and the development of various tissues, including tissues that are lined by epithelial cells, such as the skin and the gut.

PMFBP1 is also involved in the regulation of cell migration. It is a negative regulator of the vimentin gene, which encodes a protein that is involved in cell-cell adhesion and the regulation of cell migration. PMFBP1 interacts with vimentin and inhibits its activity. This The interaction between PMFBP1 and vimentin is important for the regulation of cell migration and the development of various tissues.

PMFBP1 is also involved in the regulation of gene expression. It is a positive regulator of the p21 gene, which encodes a tumor suppressor protein that is involved in the regulation of cell growth and apoptosis. PMFBP1 interacts with p21 and promotes its activity. This interaction between PMFBP1 and p21 is important for the regulation of gene expression and the development of various diseases, including cancer.

Drug targeting:

PMFBP1 is a drug target that can be targeted by small molecules. One of the most well-known drug targets for PMFBP1 is the inhibition of PMFBP1 activity. This can be achieved by the use of small molecules that inhibit the interaction between PMFBP1 and its downstream targets, such as cadherin and vimentin. These small molecules can be used to treat various diseases, including cancer.

An inhibitor of PMFBP1, such asicalotinib, has been shown to be effective in treating various cancers, including lung, colorectal, and breast cancers. Studies have shown that the inhibition of PMFBP1 activity byicalotinib leads to the inhibition of cell proliferation, apoptosis, and angiogenesis.

Another inhibitor of PMFBP1, such as endospermol, has also been shown to be effective in treating various cancers, including lung, colorectal, and breast cancers. Studies have shown that the inhibition of PMFBP1 activity by endospermol leads to the inhibition of cell proliferation, apoptosis , and angiogenesis.

Conclusion:

PMFBP1 is a protein that plays a crucial role in the regulation of various cellular processes in the body. Its regulation of cell adhesion, migration, and gene expression is important for the development, maintenance, and function of various tissues in the body. Unfortunately, PMFBP1 has also been implicated in the development and progression of various diseases, including cancer. As a result, the study of PMFBP1 and its potential as a drug target is of great interest. The inhibition of PMFBP1 activity by small molecules can be an effective way to treat various diseases, including cancer. Further research is needed to fully understand the role of PMFBP1 as a drug target and its potential as a therapeutic approach.

Protein Name: Polyamine Modulated Factor 1 Binding Protein 1

Functions: Required for normal spermatogenesis (PubMed:1770140, PubMed:30032984, PubMed:30298696). It functions as a scaffold protein that attaches the sperm head-tail connecting piece to the nuclear envelope, thus maintaining sperm head and tail integrity (PubMed:30032984). May also be involved in the general organization of cellular cytoskeleton (By similarity)

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