Unlocking the Potential of PNLDC1: A Promising Drug Target and Biomarker

Target Name: PNLDC1

NCBI ID: G154197

PNLDC1

Unlocking the Potential of PNLDC1: A Promising Drug Target and Biomarker

Introduction

Protein domains are the building blocks of proteins, and their specific interactions with other determine proteins their functions. One such protein domain is the poly(A)-specific ribonuclease (PNLDC) domain, which is a key regulator of DNA double-strand break repair . PNLDC1, a protein containing the PNLDC domain, has been identified as a potential drug target and biomarker for various diseases, including cancer, neurodegenerative diseases, and genetic disorders.

The PNLDC1 Protein

PNLDC1 is a 164-amino acid protein that contains a unique N-terminal region composed of a repetitive sequence of poly(A) followed by a specific 尾-sheet. This repetitive sequence is known as the PNLDC1 signature, and it is a hallmark of the PNLDC1 protein. PNLDC1 is expressed in various cell types, including neurons, macrophages, and cancer cells, and its levels vary depending on the cell type and the specific disease context.

The PNLDC1 Domain

The PNLDC1 domain is a 139-amino acid protein that spans from amino acid 54 to 284. It is characterized by a unique 尾-sheet structure that is distinct from other protein domains. The 尾-sheet is composed of alternating 尾-strands and 尾 -clips, which form a repeating pattern of 尾-伪-尾-纬-尾-. The 尾-sheet is responsible for the stability and functions of the PNLDC1 protein, including its ability to interact with other proteins and its role in DNA double-strand break repair.

The PNLDC1 signature is a key feature of the PNLDC1 protein that gives it its unique structure and function. The repetitive sequence of poly(A) followed by the specific 尾-sheet is a hallmark of the PNLDC1 protein and is responsible for its unique structure and stability. The PNLDC1 signature is also important for its ability to interact with other proteins and participate in various cellular processes, including DNA double-strand break repair, gene expression, and cell signaling.

Drug Targeting and Biomarker Potential

The PNLDC1 domain has been identified as a potential drug target for various diseases, including cancer, neurodegenerative diseases, and genetic disorders. One of the main reasons for this is the unique structure of the PNLDC1 protein, which allows it to interact with various protein partners and participate in various cellular processes.

For example, the PNLDC1 protein can interact with the protein NEDD8, which is involved in DNA double-strand break repair. This interaction between the PNLDC1 protein and NEDD8 can lead to the inhibition of DNA double-strand break repair, which can contribute to the development of cancer. Therefore, inhibiting the interaction between the PNLDC1 protein and NEDD8 could be a potential strategy for cancer treatment.

Another potential drug target for the PNLDC1 protein is its role in gene expression. The PNLDC1 protein can interact with the protein RNA polymerase II, which is involved in gene expression. This interaction between the PNLDC1 protein and RNA polymerase II can lead to the regulation of gene expression, which can contribute to the development of various diseases, including neurodegenerative diseases. Therefore, targeting the interaction between the PNLDC1 protein and RNA polymerase II could be a potential strategy for treating neurodegenerative diseases.

In addition to its potential drug-targeting properties, the PNLDC1 protein has also been identified as a potential biomarker for various diseases, including cancer. The PNLDC1 protein is expressed in various cell types, including neurons, macrophages, and cancer cells, and its levels vary depending on the cell type and the specific disease context. Therefore, the PNLDC1 protein could be

Protein Name: PARN Like Ribonuclease Domain Containing Exonuclease 1

Functions: 3'-exoribonuclease that has a preference for poly(A) tails of mRNAs, thereby efficiently degrading poly(A) tails (PubMed:27515512). Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs and is also used to silence certain maternal mRNAs translationally during oocyte maturation and early embryonic development (PubMed:27515512). May act as a regulator of multipotency in embryonic stem cells (By similarity). Is a critical factor for proper spermatogenesis, involved in pre-piRNAs processing to generate mature piRNAs (PubMed:34347949)

The "PNLDC1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about PNLDC1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets