POLH: A Drug Target / Disease Biomarker (G5429)

Target Name: POLH

NCBI ID: G5429

POLH

POLH: A Drug Target / Disease Biomarker

POLH, short for poly (pro)hospholipid hydrate, is a drug target and potential biomarker in the field of neurodegenerative diseases. POLH is a naturally occurring lipid molecule that is involved in various cellular processes in the brain, including the formation of the myelin sheath surrounding nerve fibers.

The myelin sheath is a critical structure that helps to transmit electrical signals along the length of the nerve fibers. However, as we age, the myelin sheath can become damaged or destroyed, leading to the development of neurodegenerative diseases such as Alzheimer's, Parkinson's, and Huntington's.

POLH has been identified as a potential drug target because it is involved in the formation of the myelin sheath and is a key player in the development of these diseases. Studies have shown that alterations in the levels of POLH in the brain can contribute to the development of neurodegenerative diseases.

One of the key mechanisms by which POLH contributes to neurodegenerative diseases is its role in the formation of aggregates, which are clusters of damaged or misfolded proteins that can accumulate in the brain and contribute to the development of neurodegeneration. Studies have shown that POLH can help to promote the formation of these aggregates, which can then contribute to the development of neurodegenerative diseases.

Another mechanism by which POLH contributes to neurodegenerative diseases is its role in the regulation of cellular processes that are critical for the survival of nerve fibers. For example, POLH has been shown to play a key role in the regulation of the production of the myelin sheath, which is critical for the survival of nerve fibers.

In addition to its role in the formation of the myelin sheath and the regulation of cellular processes, POLH has also been shown to be involved in the development of neurodegenerative diseases by altering the levels of certain proteins in the brain. For example, studies have shown that increased levels of POLH can contribute to the development of neurodegenerative diseases by altering the levels of certain proteins, such as tau and beta-amyloid.

Overall, POLH is a drug target and potential biomarker in the field of neurodegenerative diseases due to its involvement in the formation of the myelin sheath and its role in the regulation of cellular processes that are critical for the survival of nerve fibers. Further research is needed to fully understand the role of POLH in the development and treatment of neurodegenerative diseases.

Protein Name: DNA Polymerase Eta

Functions: DNA polymerase specifically involved in the DNA repair by translesion synthesis (TLS) (PubMed:10385124, PubMed:11743006, PubMed:24449906, PubMed:24553286, PubMed:16357261). Due to low processivity on both damaged and normal DNA, cooperates with the heterotetrameric (REV3L, REV7, POLD2 and POLD3) POLZ complex for complete bypass of DNA lesions. Inserts one or 2 nucleotide(s) opposite the lesion, the primer is further extended by the tetrameric POLZ complex. In the case of 1,2-intrastrand d(GpG)-cisplatin cross-link, inserts dCTP opposite the 3' guanine (PubMed:24449906). Particularly important for the repair of UV-induced pyrimidine dimers (PubMed:10385124, PubMed:11743006). Although inserts the correct base, may cause base transitions and transversions depending upon the context. May play a role in hypermutation at immunoglobulin genes (PubMed:11376341, PubMed:14734526). Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does not have any lyase activity, preventing the release of the 5'-deoxyribose phosphate (5'-dRP) residue. This covalent trapping of the enzyme by the 5'-dRP residue inhibits its DNA synthetic activity during base excision repair, thereby avoiding high incidence of mutagenesis (PubMed:14630940). Targets POLI to replication foci (PubMed:12606586)

The "POLH Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about POLH comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets