POFUT1: A Protein in Intracellular Signaling Pathways and The Regulation of Cellular Processes

Target Name: POFUT1

NCBI ID: G23509

POFUT1

POFUT1: A Protein in Intracellular Signaling Pathways and The Regulation of Cellular Processes

POFUT1 (Pyruvate Kinase 1) is a gene that has been identified as a potential drug target or biomarker for the treatment of various diseases, including cancer, neurodegenerative diseases, and metabolic disorders.

The POFUT1 gene is a member of the Pyruvate Kinase family, which is a group of enzymes that are involved in the metabolism of pyruvate, a critical intermediate step in the citric acid cycle. These enzymes are known to play a crucial role in the regulation of cellular metabolism and have been implicated in the development and progression of various diseases.

Research has shown that POFUT1 is involved in the regulation of a wide range of cellular processes, including cell growth, differentiation, and metabolism. It has been shown to play a role in the development and progression of various diseases, including cancer, neurodegenerative diseases, and metabolic disorders.

One of the key features of POFUT1 is its role in the regulation of cellular metabolism. This is important because changes in cellular metabolism can have a significant impact on the health and function of cells. For example, disruptions in metabolism can lead to the development of cancer, neurodegenerative diseases, and other disorders.

In addition to its role in cellular metabolism, POFUT1 has also been shown to play a key role in the regulation of cellular signaling. This is important because signaling processes are critical for the development and maintenance of cellular organization and homeostasis.

The POFUT1 gene has also been shown to be involved in the regulation of cellular adhesion. This is important because adhesion is a critical aspect of the development and maintenance of tissues and organs, and changes in adhesion can contribute to the development of various diseases.

Overall, the POFUT1 gene is a promising drug target or biomarker for the treatment of various diseases. Further research is needed to fully understand its role in the regulation of cellular metabolism, signaling, and adhesion, and to develop effective treatments based on these insights.

Protein Name: Protein O-fucosyltransferase 1

Functions: Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine residue found in the consensus sequence C2-X(4,5)-[S/T]-C3 of EGF domains, where C2 and C3 are the second and third conserved cysteines. Specifically uses GDP-fucose as donor substrate and proper disulfide pairing of the substrate EGF domains is required for fucose transfer. Plays a crucial role in NOTCH signaling. Initial fucosylation of NOTCH by POFUT1 generates a substrate for FRINGE/RFNG, an acetylglucosaminyltransferase that can then extend the fucosylation on the NOTCH EGF repeats. This extended fucosylation is required for optimal ligand binding and canonical NOTCH signaling induced by DLL1 or JAGGED1. Fucosylates AGRN and determines its ability to cluster acetylcholine receptors (AChRs)

The "POFUT1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about POFUT1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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