POLDIP2: Key Component of DNA Replication in Eukaryotic Cells

Target Name: POLDIP2

NCBI ID: G26073

POLDIP2

POLDIP2: Key Component of DNA Replication in Eukaryotic Cells

POLDIP2 (DNA polymerase delta interacting protein 2) is a protein that plays a crucial role in the process of DNA replication in eukaryotic cells. It is a key component of the replication machinery, which is responsible for the production of new DNA copies during cell division. POLDIP2 is a 21-kDa protein that contains a unique domain that allows it to interact with the DNA polymerase II. This interaction between POLDIP2 and DNA polymerase II is critical for the proper functioning of the replication machinery.

The Importance of DNA Replication

DNA replication is a critical process for eukaryotic cells to produce new genetic information during cell division. It is a complex process that involves the interaction of multiple proteins, including DNA polymerase II, which is the enzyme responsible for producing the new DNA copies. POLDIP2 is one of the proteins that interacts with DNA polymerase II.

POLDIP2 and DNA polymerase II Interaction

POLDIP2 is a protein that contains a unique domain that is able to interact with DNA polymerase II. This interaction between POLDIP2 and DNA polymerase II is critical for the proper functioning of the replication machinery. POLDIP2 functions as a negative regulator of DNA polymerase II, which means that it inhibits the activity of DNA polymerase II.

POLDIP2 Interacts with Multiple Proteins

POLDIP2 is not a standalone protein, and it interacts with several other proteins during the replication process. One of the most significant interactions between POLDIP2 and DNA polymerase II is the interaction between POLDIP2 and the protein named MBD2. MBD2 is a non-histone protein that is involved in the regulation of DNA replication. It interacts with POLDIP2 and helps to regulate the activity of DNA polymerase II.

POLDIP2 also interacts with the protein named SIRT1. SIRT1 is a NAD+-dependent protein that is involved in the regulation of various cellular processes, including DNA replication. It interacts with POLDIP2 and helps to regulate the activity of DNA polymerase II.

POLDIP2 is also interacted with the protein named TIP600, which is a protein that is involved in the regulation of DNA replication. TIP600 interacts with POLDIP2 and helps to regulate the activity of DNA polymerase II.

Mutations in POLDIP2

Mutations in POLDIP2 have been observed that can affect the function of the replication machinery. One of the most significant mutations is a missense mutation, which is a change in the amino acid sequence of a protein. This mutation can affect the interaction between POLDIP2 and DNA polymerase II, which can in turn affect the function of the replication machinery.

Another type of mutation that has been observed in POLDIP2 is a structural mutation. These mutations can affect the structure and function of POLDIP2, which can in turn affect its interaction with DNA polymerase II.

Conclusion

POLDIP2 is a protein that plays a crucial role in the process of DNA replication in eukaryotic cells. It is a key component of the replication machinery and is involved in the interaction with DNA polymerase II. Mutations in POLDIP2 can affect the function of the replication machinery, and therefore it may be a drug target or biomarker. Further research is needed to fully understand the role of POLDIP2 in DNA replication and its potential as a drug target or biomarker.

Protein Name: DNA Polymerase Delta Interacting Protein 2

Functions: Involved in DNA damage tolerance by regulating translesion synthesis (TLS) of templates carrying DNA damage lesions such as 8oxoG and abasic sites (PubMed:24191025). May act by stimulating activity of DNA polymerases involved in TLS, such as PRIMPOL and polymerase delta (POLD1) (PubMed:24191025, PubMed:26984527)

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