PNPT1: Key Player in Cellular Processes (G87178)

Target Name: PNPT1

NCBI ID: G87178

PNPT1

PNPT1: Key Player in Cellular Processes

PNPT1 (Proteasome-Nucleated Protein-Trap) is a protein that is expressed in various tissues throughout the body, including the brain, muscle, and liver. It is a key player in the proteasome system, which is a mechanism by which the body removes damaged or unnecessary proteins from its cells. PNPT1 has been shown to play a role in the regulation of a variety of cellular processes, including cell growth, apoptosis (programmed cell death), and neurodegeneration.

One of the unique features of PNPT1 is its ability to form a protein-protein interaction complex with other proteins. This interaction is known as a \"trapping\" interaction, which allows PNPT1 to capture and immobilize other proteins that are in the same general sub-cellular location. This interaction between PNPT1 and other proteins is critical for the regulation of cellular processes, including the control of protein levels and the timing of protein-protein interactions.

In addition to its role in protein-protein interaction, PNPT1 has also been shown to play a critical role in the regulation of cell apoptosis. Apoptosis is a natural process that is essential for the development and maintenance of tissues and organs, but it can also be a hallmark of disease and dysfunction. The regulation of apoptosis is critical for the survival of cells and organisms, and PNPT1 has been shown to play a key role in this process.

Studies have shown that PNPT1 is involved in the regulation of apoptosis in a variety of cellular contexts, including neurons, muscle cells, and cancer cells. For example, researchers have shown that PNPT1 is involved in the regulation of cell apoptosis in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. They have also shown that PNPT1 is involved in the regulation of muscle cell apoptosis, which is a common cause of muscle weakness and wasting in older adults.

In addition to its role in apoptosis, PNPT1 has also been shown to play a critical role in the regulation of cell growth and metabolism. This is important for the development and maintenance of tissues and organs, and is also critical for the regulation of tissue homeostasis.

The regulation of cell growth and metabolism is a complex process that is controlled by a variety of proteins, including PNPT1. Studies have shown that PNPT1 is involved in the regulation of cell growth and metabolism in a variety of cellular contexts, including tissues and organs, and that it plays a key role in the regulation of cell cycle progression and the maintenance of cellular processes.

In conclusion, PNPT1 is a protein that is involved in a variety of cellular processes that are critical for the development and maintenance of tissues and organs. Its role in protein-protein interaction and in the regulation of apoptosis, cell growth, and metabolism makes it an attractive drug target and a potential biomarker for a variety of diseases. Further research is needed to fully understand the mechanisms of PNPT1's role in these processes and to develop effective therapies based on this protein.

Protein Name: Polyribonucleotide Nucleotidyltransferase 1

Functions: RNA-binding protein implicated in numerous RNA metabolic processes. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'-to-5' direction. Mitochondrial intermembrane factor with RNA-processing exoribonulease activity. Component of the mitochondrial degradosome (mtEXO) complex, that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner. Involved in the degradation of non-coding mitochondrial transcripts (MT-ncRNA) and tRNA-like molecules (PubMed:29967381). Required for correct processing and polyadenylation of mitochondrial mRNAs. Plays a role as a cytoplasmic RNA import factor that mediates the translocation of small RNA components, like the 5S RNA, the RNA subunit of ribonuclease P and the mitochondrial RNA-processing (MRP) RNA, into the mitochondrial matrix. Plays a role in mitochondrial morphogenesis and respiration; regulates the expression of the electron transport chain (ETC) components at the mRNA and protein levels. In the cytoplasm, shows a 3'-to-5' exoribonuclease mediating mRNA degradation activity; degrades c-myc mRNA upon treatment with IFNB1/IFN-beta, resulting in a growth arrest in melanoma cells. Regulates the stability of specific mature miRNAs in melanoma cells; specifically and selectively degrades miR-221, preferentially. Also plays a role in RNA cell surveillance by cleaning up oxidized RNAs. Binds to the RNA subunit of ribonuclease P, MRP RNA and miR-221 microRNA

The "PNPT1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about PNPT1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets