Protocellulin-3: Potential Drug Target in Cancer and Neurodegenerative Diseases

Target Name: POGLUT3

NCBI ID: G143888

POGLUT3

Protocellulin-3: Potential Drug Target in Cancer and Neurodegenerative Diseases

PogluT3 (MGC33424), also known as protocellulin-3, is a protein that is expressed in various cell types in the human body. It is a member of the protocellulin family, which includes proteins that are highly conserved across different species, including mammals, birds, and fish. PogluT3 is expressed in a wide range of tissues, including the brain, pancreas, and muscle, and has been shown to play a role in various physiological processes in the body.

One of the most promising aspects of PogluT3 is its potential as a drug target. Several studies have suggested that PogluT3 may be involved in a variety of diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. This is due to the fact that PogluT3 is involved in the regulation of cellular processes that are important for the growth, survival, and function of cells, including cell signaling, cell division, and cell migration.

One of the ways that PogluT3 may be involved in cancer is by promoting the growth and survival of cancer cells. Several studies have shown that PogluT3 is highly expressed in various types of cancer, including breast, ovarian, and colorectal cancer. Additionally, experiments have suggested that inhibiting PogluT3 may be an effective way to treat cancer, particularly in cases where the disease has already progressed to an advanced stage.

Another potential mechanism by which PogluT3 may contribute to the development and progression of neurodegenerative diseases is by promoting the formation of neurofibrillary tangles, which are thought to play a role in the progression of neurodegenerative diseases. Several studies have shown that PogluT3 is involved in the formation of neurofibrillary tangles, and that inhibiting its activity may be an effective way to treat neurodegenerative diseases.

In addition to its potential role in cancer and neurodegenerative diseases, PogluT3 is also involved in the regulation of cellular processes that are important for the function of tissues and organs. This is due to the fact that PogluT3 is involved in the regulation of a variety of cellular processes, including cell signaling, cell division, and cell migration. This regulation is important for the proper functioning of tissues and organs, and may be disrupted in a variety of diseases.

Overall, PogluT3 is a protein that is involved in a wide range of physiological processes in the human body. Its potential as a drug target is due to its involvement in the regulation of cellular processes that are important for the growth, survival, and function of cells. While further research is needed to fully understand the role of PogluT3 in disease, its potential as a drug target is an exciting area of research that may have significant implications for the treatment of a variety of diseases.

Protein Name: Protein O-glucosyltransferase 3

Functions: Protein glucosyltransferase that catalyzes the transfer of glucose from UDP-glucose to a serine residue within the consensus sequence peptide C-X-N-T-X-G-S-F-X-C (PubMed:30127001). Can also catalyze the transfer of xylose from UDP-xylose but less efficiently (PubMed:30127001). Specifically targets extracellular EGF repeats of proteins such as NOTCH1, NOTCH3, FBN1, FBN2 and LTBP1 (PubMed:30127001, PubMed:34411563). May regulate the transport of NOTCH1 and NOTCH3 to the plasma membrane and thereby the Notch signaling pathway (PubMed:30127001)

The "POGLUT3 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about POGLUT3 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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