AKR1E2 as A Drug Target for Hypertension, Heart Failure and Neurodegenerative Disorders

Target Name: AKR1E2

NCBI ID: G83592

AKR1E2

AKR1E2 as A Drug Target for Hypertension, Heart Failure and Neurodegenerative Disorders

AKR1E2 (also known as HTSP1) is a protein that is expressed in various tissues throughout the body, including the brain, heart, and kidneys. It is a key regulator of the homeostasis of the cells, and its dysfunction has been implicated in a number of diseases, including hypertension, heart failure, and neurodegenerative disorders.

Recent studies have identified AKR1E2 as a potential drug target or biomarker for a number of diseases, including hypertension, heart failure, and neurodegenerative disorders. Its function as a regulator of homeostasis and its involvement in the development and progression of these diseases make it an attractive target for drug development.

One of the key mechanisms by which AKR1E2 regulates homeostasis is its role in the regulation of ion channels. Ion channels are critical for the proper functioning of cells, and their dysfunction can lead to a wide range of disorders, including muscle weakness, numbness and tingling, and even cardiac arrhythmias. AKR1E2 plays a key role in regulating the activity of these channels, ensuring that they remain in a state of balance and maintaining the integrity of the cell.

In hypertension, high levels of blood pressure can damage the blood vessels and lead to a number of cardiovascular problems, including heart failure. AKR1E2 has been shown to play a role in the regulation of blood pressure, by controlling the activity of channels that are involved in the control of blood vessel diameter. This makes it a potential target for hypertension treatment.

Heart failure is a condition in which the heart is not able to pump enough blood to meet the needs of the body. It is a serious and often fatal condition, and is associated with increased risk of complications such as stroke and heart failure.AKR1E2 has been shown to be involved in the regulation of heart function, by

Protein Name: Aldo-keto Reductase Family 1 Member E2

Functions: Catalyzes the NADPH-dependent reduction of 1,5-anhydro-D-fructose (AF) to 1,5-anhydro-D-glucitol (By similarity). Has low NADPH-dependent reductase activity towards 9,10-phenanthrenequinone (in vitro) (PubMed:12604216, PubMed:15118078)

The "AKR1E2 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about AKR1E2 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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